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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="tareload" data-source="post: 189382"><p>[URL unfurl="true"]https://tru-t.org/evidence/#existing-calculators-are-inaccurate[/URL]</p><p></p><p><em>Prevailing calculators are inaccurate</em></p><p><em></em></p><p><em><span style="color: rgb(184, 49, 47)">It has been demonstrated that the calculated free testosterone derived using commonly available online calculators, which are based on simpler models assuming simple 1:1 binding of testosterone and SHBG [1,2], deviate from measurements obtained by equilibrium dialysis by as much as 40% [3-9].</span></em></p><p></p><p></p><p>This is a true statement. The only issue is that Tru-T is even more inaccurate than the simple linear models.</p><p></p><p></p><p>The purported reference range for Adult male free T (16-31 ng/dL) based on Tru-T model does not match the reference ranges from 4 major reference laboratories in the US.</p><p></p><p></p><p>Compare the ranges in the paper below to the reference ranges from US reference laboratories I just shared above. Was there an artifact in the equilibrium dialysis method the authors used to validate their model? The ranges below are higher (and low is skewed higher) compared to US reference laboratories.</p><p></p><p>Gen 3 reference range below converted to nd/dL: 16.3-31.3</p><p></p><p>[URL unfurl="true"]https://www.sciencedirect.com/science/article/abs/pii/S030372071400272X?via%3Dihub[/URL]</p><p></p><p></p><p>[ATTACH=full]11222[/ATTACH]</p></blockquote><p></p>
[QUOTE="tareload, post: 189382"] [URL unfurl="true"]https://tru-t.org/evidence/#existing-calculators-are-inaccurate[/URL] [I]Prevailing calculators are inaccurate [COLOR=rgb(184, 49, 47)]It has been demonstrated that the calculated free testosterone derived using commonly available online calculators, which are based on simpler models assuming simple 1:1 binding of testosterone and SHBG [1,2], deviate from measurements obtained by equilibrium dialysis by as much as 40% [3-9].[/COLOR][/I] This is a true statement. The only issue is that Tru-T is even more inaccurate than the simple linear models. The purported reference range for Adult male free T (16-31 ng/dL) based on Tru-T model does not match the reference ranges from 4 major reference laboratories in the US. Compare the ranges in the paper below to the reference ranges from US reference laboratories I just shared above. Was there an artifact in the equilibrium dialysis method the authors used to validate their model? The ranges below are higher (and low is skewed higher) compared to US reference laboratories. Gen 3 reference range below converted to nd/dL: 16.3-31.3 [URL unfurl="true"]https://www.sciencedirect.com/science/article/abs/pii/S030372071400272X?via%3Dihub[/URL] [ATTACH type="full" alt="1603385614839.png"]11222[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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