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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="Cataceous" data-source="post: 189368" data-attributes="member: 38109"><p>It does seem like a significant discrepancy. Maybe we should just revert to using one of the empirical formulas mentioned in your other post:</p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/reassessing-free-testosterone-calculation-by-liquid-chromatography–tandem-mass-spectrometry-direct-equilibrium-dialysis.16161/#post-189340[/URL]</p><p>I looked up the one from Sartorius et al. It is straightforward:</p><p></p><p>cFT (pMol/L) = 24.00314 * T / log10(SHBG) - 0.04599 * T * T</p><p>T and SHBG in nMol/L</p><p>T(ng/dL) = 28.8184 * T(nMol/L)</p><p>FT(ng/dL) = FT(pMol/L) / 1000 * 28.8184</p><p></p><p>One nice thing is that the numbers somewhat align with Quest's equilibrium dialysis test, which has a reference range of 3.5-15.5 ng/dL. Using an SHBG of 30 nMol/L has this reference range corresponding to total testosterone ranging from just over 200 ng/dL to just under 1,100 ng/dL. Is it a coincidence that this corresponds to Quest's reference range for LC/MS total testosterone?</p></blockquote><p></p>
[QUOTE="Cataceous, post: 189368, member: 38109"] It does seem like a significant discrepancy. Maybe we should just revert to using one of the empirical formulas mentioned in your other post: [URL unfurl="true"]https://www.excelmale.com/forum/threads/reassessing-free-testosterone-calculation-by-liquid-chromatography–tandem-mass-spectrometry-direct-equilibrium-dialysis.16161/#post-189340[/URL] I looked up the one from Sartorius et al. It is straightforward: cFT (pMol/L) = 24.00314 * T / log10(SHBG) - 0.04599 * T * T T and SHBG in nMol/L T(ng/dL) = 28.8184 * T(nMol/L) FT(ng/dL) = FT(pMol/L) / 1000 * 28.8184 One nice thing is that the numbers somewhat align with Quest's equilibrium dialysis test, which has a reference range of 3.5-15.5 ng/dL. Using an SHBG of 30 nMol/L has this reference range corresponding to total testosterone ranging from just over 200 ng/dL to just under 1,100 ng/dL. Is it a coincidence that this corresponds to Quest's reference range for LC/MS total testosterone? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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