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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="tareload" data-source="post: 189361"><p><span style="font-size: 22px"><strong>Methods</strong></span></p><p>Medical records were reviewed retrospectively from adult men who presented for a clinical evaluation of adult onset hypogonadism (<em>n</em> = 33), and from adult men who were being treated for hypogonadism with transdermal testosterone (<em>n</em> = 25).</p><p>The men with AOH presented for evaluation because of erectile dysfunction, low libido and/or asthenia. A thorough medical history and physical examination were performed, and classical causes of hypogonadism were excluded, in most cases by additional endocrine testing. Testis size was ≥ 20 mL. 6 men had diabetes, and 16 were being treated for dyslipidemia.</p><p>Testosterone-treated men had been diagnosed with adult onset hypogonadism (<em>n</em> = 12), hypopituitarism (<em>n</em> = 9), congenital hypogonadotropic hypogonadism (<em>n</em> = 2), or Klinefelter syndrome (<em>n</em> = 2), and were being treated with a stable dose of a transdermal testosterone preparation.</p><p><em><span style="color: rgb(184, 49, 47)">Assays were performed at Quest Diagnostics. Testosterone levels were measured by liquid chromatography-mass spectrometry, and SHBG was measured by immunoassay. Free testosterone was measured by indirect equilibrium dialysis. Laboratory reference ranges for adult men are: 250–1100 ng/dL for total testosterone, 10–50 nmol/L for SHBG, and 35–155 pg/mL for free testosterone.</span></em></p><p><span style="font-size: 18px"><strong>Statistical analysis</strong></span></p><p>Two group comparisons were performed using Student’s t-test or the Mann–Whitney Rank Sum test when data were not normally distributed or groups had unequal variance. Pearson correlation coefficients were calculated using SigmaStat/Systat Software, Inc. (San Jose, CA). Data are presented as the mean ± SD or the median and 25–75% range.</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p>Try fitting these data with either Vermeulen or Tru-T:</p><p>[ATTACH=full]11204[/ATTACH]</p><p></p><p>[ATTACH=full]11203[/ATTACH]</p><p></p><p>The only ED free T data I can find in the literature that fits the Tru-T calculator is the data presented in the Tru-T papers. All the other free T ED data I've scanned (again not exhaustive) shows Vermeulen overpredicts and Tru-T WAY overpredicts measured free T.</p><p></p><p>You guys have other parity plots vs Tru-T vs Vermeulen with equilibrium dialysis data?</p></blockquote><p></p>
[QUOTE="tareload, post: 189361"] [SIZE=22px][B]Methods[/B][/SIZE] Medical records were reviewed retrospectively from adult men who presented for a clinical evaluation of adult onset hypogonadism ([I]n[/I] = 33), and from adult men who were being treated for hypogonadism with transdermal testosterone ([I]n[/I] = 25). The men with AOH presented for evaluation because of erectile dysfunction, low libido and/or asthenia. A thorough medical history and physical examination were performed, and classical causes of hypogonadism were excluded, in most cases by additional endocrine testing. Testis size was ≥ 20 mL. 6 men had diabetes, and 16 were being treated for dyslipidemia. Testosterone-treated men had been diagnosed with adult onset hypogonadism ([I]n[/I] = 12), hypopituitarism ([I]n[/I] = 9), congenital hypogonadotropic hypogonadism ([I]n[/I] = 2), or Klinefelter syndrome ([I]n[/I] = 2), and were being treated with a stable dose of a transdermal testosterone preparation. [I][COLOR=rgb(184, 49, 47)]Assays were performed at Quest Diagnostics. Testosterone levels were measured by liquid chromatography-mass spectrometry, and SHBG was measured by immunoassay. Free testosterone was measured by indirect equilibrium dialysis. Laboratory reference ranges for adult men are: 250–1100 ng/dL for total testosterone, 10–50 nmol/L for SHBG, and 35–155 pg/mL for free testosterone.[/COLOR][/I] [SIZE=18px][B]Statistical analysis[/B][/SIZE] Two group comparisons were performed using Student’s t-test or the Mann–Whitney Rank Sum test when data were not normally distributed or groups had unequal variance. Pearson correlation coefficients were calculated using SigmaStat/Systat Software, Inc. (San Jose, CA). Data are presented as the mean ± SD or the median and 25–75% range. Try fitting these data with either Vermeulen or Tru-T: [ATTACH type="full" alt="1603377913290.png"]11204[/ATTACH] [ATTACH type="full" alt="1603377858130.png"]11203[/ATTACH] The only ED free T data I can find in the literature that fits the Tru-T calculator is the data presented in the Tru-T papers. All the other free T ED data I've scanned (again not exhaustive) shows Vermeulen overpredicts and Tru-T WAY overpredicts measured free T. You guys have other parity plots vs Tru-T vs Vermeulen with equilibrium dialysis data? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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