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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="Cataceous" data-source="post: 177348" data-attributes="member: 38109"><p>On TRT, testosterone regulation is disabled due to HPTA shutdown. It's true that excess androgens typically reduce SHBG, though this takes place over weeks to months, and the phenomenon doesn't affect the argument that free testosterone is proportional to dose. The consequence of falling SHBG is falling total testosterone. This then maintains free testosterone as it was.</p><p></p><p>If the idea is too simple to be true then one of the two points I listed above must be wrong. The idea of testosterone consumption equaling testosterone input at steady state seems almost self-evident and hard to attack. It's a little easier to criticize the concept of hormone usage being proportional to concentration, though the idea is <a href="https://www.glowm.com/section_view/heading/Production,+Clearance,+and+Measurement+of+Steroid+Hormones/item/277" target="_blank">widely accepted</a>. The model probably isn't perfect over all forms of testosterone metabolism. Nonetheless, it seems likely that any errors are small enough to ignore.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 177348, member: 38109"] On TRT, testosterone regulation is disabled due to HPTA shutdown. It's true that excess androgens typically reduce SHBG, though this takes place over weeks to months, and the phenomenon doesn't affect the argument that free testosterone is proportional to dose. The consequence of falling SHBG is falling total testosterone. This then maintains free testosterone as it was. If the idea is too simple to be true then one of the two points I listed above must be wrong. The idea of testosterone consumption equaling testosterone input at steady state seems almost self-evident and hard to attack. It's a little easier to criticize the concept of hormone usage being proportional to concentration, though the idea is [URL='https://www.glowm.com/section_view/heading/Production,+Clearance,+and+Measurement+of+Steroid+Hormones/item/277']widely accepted[/URL]. The model probably isn't perfect over all forms of testosterone metabolism. Nonetheless, it seems likely that any errors are small enough to ignore. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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