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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="Cataceous" data-source="post: 177312" data-attributes="member: 38109"><p>In fact I do expect a little rise post-injection in these cases, but it's not enough to affect the results. I did measure consistent values pre-injection and day-after injection on the EOD schedule.</p><p></p><p></p><p>The literature on TRT does not support the notion of arbitrary variations in T or free T. The creators of free T calculations believe that it's possible to obtain a fairly accurate value for free testosterone based on total testosterone, SHBG, etc. If you prefer to reject that then it's beyond my purview. But the calculation of free T is not essential to the underlying principles; it just allows a nice demonstration of them. The Law of Mass Action is accepted theory, and harder to reject.</p><p></p><p>There are two basic principles: 1) If we're putting testosterone in at a steady rate then at steady state it's being used up at the same rate. 2) The rate of use is proportional to the free hormone concentration. Therefore, free testosterone is proportional to the amount of testosterone we're putting in.</p><p></p><p>Is there additional complexity beyond this model? Most likely. Does it matter in most cases? Probably not.</p><p></p><p></p><p>This is par for the course. Different assays produce very different results. The direct assays are typically giving results around 10-30 pg/mL, which is off by a factor of 10 from the true concentrations. It would be ok if they correlated well with more accurate tests, but they don't do that either. The point of the Tru-T calculator is attain better correlation with the most accurate testing method, which it does.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 177312, member: 38109"] In fact I do expect a little rise post-injection in these cases, but it's not enough to affect the results. I did measure consistent values pre-injection and day-after injection on the EOD schedule. The literature on TRT does not support the notion of arbitrary variations in T or free T. The creators of free T calculations believe that it's possible to obtain a fairly accurate value for free testosterone based on total testosterone, SHBG, etc. If you prefer to reject that then it's beyond my purview. But the calculation of free T is not essential to the underlying principles; it just allows a nice demonstration of them. The Law of Mass Action is accepted theory, and harder to reject. There are two basic principles: 1) If we're putting testosterone in at a steady rate then at steady state it's being used up at the same rate. 2) The rate of use is proportional to the free hormone concentration. Therefore, free testosterone is proportional to the amount of testosterone we're putting in. Is there additional complexity beyond this model? Most likely. Does it matter in most cases? Probably not. This is par for the course. Different assays produce very different results. The direct assays are typically giving results around 10-30 pg/mL, which is off by a factor of 10 from the true concentrations. It would be ok if they correlated well with more accurate tests, but they don't do that either. The point of the Tru-T calculator is attain better correlation with the most accurate testing method, which it does. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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