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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="Cataceous" data-source="post: 177201" data-attributes="member: 38109"><p>The slowly changing absorption rate of an injected testosterone ester is just a distraction here. The theory is better understood by thinking of the limit, in which identical tiny amounts of the ester are injected at such frequent intervals that the absorption rate is effectively constant, and of course is proportional to the individual doses. The proportionality constant is the "k" above; it doesn't change. MCR, the metabolic clearance rate, is generally considered to be a constant, even though it is dependent on many underlying factors. The fact that mine hasn't changed over a significant time period is at least suggestive that it can be fairly stable.</p><p></p><p>What I'm showing is that average free testosterone is proportional to dose if the same dose is administered at constant intervals. In the limiting case where the inter-dose interval goes to zero then free testosterone becomes constant. It doesn't take anything extreme to create these conditions: Every-other-day dosing of cypionate or enathate leads to nearly constant testosterone levels.</p><p></p><p style="margin-left: 20px"><em>If that is the case, and the calculator uses a formula highly linear with respect to the total testosterone and not very dependent on the other variables, you will get a near perfect straight line between dose and free testosterone from the calculator.</em></p><p></p><p>This only describes a case with unchanging SHBG. One of the points of this exercise is to show that changes in SHBG lead to changes in total testosterone, not changes in free testosterone, at least after stabilization. The concept is intuitively better understood with reference to a fluid flow analogy, which I presented <a href="https://www.peaktestosterone.com/forum/index.php?topic=15786.0" target="_blank">here</a>.</p><p></p><p>These ideas are based on currently accepted models, so I am fairly confident in the general principles, but acknowledge that I'd like to see other guys collecting data to verify the linearity. In fact, I think this kind of calibration should be a first step in TRT for anyone. It's very useful to establish a dose-response relationship that can be used to predict testosterone levels from any dose.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 177201, member: 38109"] The slowly changing absorption rate of an injected testosterone ester is just a distraction here. The theory is better understood by thinking of the limit, in which identical tiny amounts of the ester are injected at such frequent intervals that the absorption rate is effectively constant, and of course is proportional to the individual doses. The proportionality constant is the "k" above; it doesn't change. MCR, the metabolic clearance rate, is generally considered to be a constant, even though it is dependent on many underlying factors. The fact that mine hasn't changed over a significant time period is at least suggestive that it can be fairly stable. What I'm showing is that average free testosterone is proportional to dose if the same dose is administered at constant intervals. In the limiting case where the inter-dose interval goes to zero then free testosterone becomes constant. It doesn't take anything extreme to create these conditions: Every-other-day dosing of cypionate or enathate leads to nearly constant testosterone levels. [INDENT][I]If that is the case, and the calculator uses a formula highly linear with respect to the total testosterone and not very dependent on the other variables, you will get a near perfect straight line between dose and free testosterone from the calculator.[/I][/INDENT] This only describes a case with unchanging SHBG. One of the points of this exercise is to show that changes in SHBG lead to changes in total testosterone, not changes in free testosterone, at least after stabilization. The concept is intuitively better understood with reference to a fluid flow analogy, which I presented [URL='https://www.peaktestosterone.com/forum/index.php?topic=15786.0']here[/URL]. These ideas are based on currently accepted models, so I am fairly confident in the general principles, but acknowledge that I'd like to see other guys collecting data to verify the linearity. In fact, I think this kind of calibration should be a first step in TRT for anyone. It's very useful to establish a dose-response relationship that can be used to predict testosterone levels from any dose. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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