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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="Cataceous" data-source="post: 177093" data-attributes="member: 38109"><p>I admit the data look too good to be true, but they are the real deal. The only small fudge is that there are a couple other data points not used in this graph that are just off the line. They only reduce R-squared a little, and were trending away from an origin intercept. I wanted to get the best dose-response estimate to use for future predictions. The graph with all seven data points is in another thread somewhere.</p><p></p><p>The linearity is because free testosterone should basically be proportional to dose, not because of anything to do with Tru-T. It's just that Tru-T is giving a better estimate of free T than Vermeulen, the direct measurement, etc. The reasoning on proportionality is this: The rate of testosterone absorption in TRT is proportional to dose. The law of mass action says that the production rate (absorption rate in TRT) is proportional to the hormone concentration, free testosterone in this case. So:</p><p></p><p>k * dose = production_rate = MCR * free_T = MCR * f(T, SHBG)</p><p></p><p>where MCR is a metabolic clearance rate constant. This means:</p><p></p><p>free_T = constant * dose</p><p></p><p>I've noted that there aren't guarantees that MCR won't change over time. But my results show that mine has been stable over a period of five years, and with SHBG values ranging from 20s to 40s nMol/L.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 177093, member: 38109"] I admit the data look too good to be true, but they are the real deal. The only small fudge is that there are a couple other data points not used in this graph that are just off the line. They only reduce R-squared a little, and were trending away from an origin intercept. I wanted to get the best dose-response estimate to use for future predictions. The graph with all seven data points is in another thread somewhere. The linearity is because free testosterone should basically be proportional to dose, not because of anything to do with Tru-T. It's just that Tru-T is giving a better estimate of free T than Vermeulen, the direct measurement, etc. The reasoning on proportionality is this: The rate of testosterone absorption in TRT is proportional to dose. The law of mass action says that the production rate (absorption rate in TRT) is proportional to the hormone concentration, free testosterone in this case. So: k * dose = production_rate = MCR * free_T = MCR * f(T, SHBG) where MCR is a metabolic clearance rate constant. This means: free_T = constant * dose I've noted that there aren't guarantees that MCR won't change over time. But my results show that mine has been stable over a period of five years, and with SHBG values ranging from 20s to 40s nMol/L. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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