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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="xqfq" data-source="post: 161503" data-attributes="member: 38167"><p>While this calculator is, I’m sure, much better than he existing alternatives, I wonder if it’s missing some possible variables.</p><p></p><p>Most notably, I’ve read about how magnesium effects SHBG <-> Testosterone binding affinity. According to this paper:</p><p></p><p><a href="https://www.hindawi.com/journals/ije/2014/525249/" target="_blank">The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men</a></p><p></p><p>“Excoffon and colleagues provided evidence of a magnesium-mediated variation in the T-SHBG affinity. The change in magnesium levels inside the biological serum concentration range (0.75–0.95 mM) could lead to an enhancement of the Bio-T. In fact, <strong>the affinity of T to SHBG seems to change slightly with the magnesium concentration.</strong> Magnesium binds SHBG in a nonspecific mode, leading to an uncompetitive inhibition with T in binding SHBG and to a subsequent enhancement of Bio-T availability.”</p><p></p><div style="text-align: justify; max-width: %s">So based on this paper, serum magnesium concentration may be a necessary variable for accurate free testosterone calculation.</div> </p><div style="text-align: justify; max-width: %s">I believe boron works in a similar way, increasing the availability of magnesium somehow.</div> </p><p>I know the researchers showed their TruT model matching closely with the better free T blood tests, but I wonder if there would be a discrepancy in individuals who heavily supplement magnesium or are otherwise more deficient in magnesium.</p></blockquote><p></p>
[QUOTE="xqfq, post: 161503, member: 38167"] While this calculator is, I’m sure, much better than he existing alternatives, I wonder if it’s missing some possible variables. Most notably, I’ve read about how magnesium effects SHBG <-> Testosterone binding affinity. According to this paper: [URL='https://www.hindawi.com/journals/ije/2014/525249/']The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men[/URL] “Excoffon and colleagues provided evidence of a magnesium-mediated variation in the T-SHBG affinity. The change in magnesium levels inside the biological serum concentration range (0.75–0.95 mM) could lead to an enhancement of the Bio-T. In fact, [B]the affinity of T to SHBG seems to change slightly with the magnesium concentration.[/B] Magnesium binds SHBG in a nonspecific mode, leading to an uncompetitive inhibition with T in binding SHBG and to a subsequent enhancement of Bio-T availability.” [JUSTIFY]So based on this paper, serum magnesium concentration may be a necessary variable for accurate free testosterone calculation.[/JUSTIFY] [JUSTIFY]I believe boron works in a similar way, increasing the availability of magnesium somehow.[/JUSTIFY] I know the researchers showed their TruT model matching closely with the better free T blood tests, but I wonder if there would be a discrepancy in individuals who heavily supplement magnesium or are otherwise more deficient in magnesium. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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