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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="in_TRT" data-source="post: 146646" data-attributes="member: 38777"><p>The older papers have too many simplistic assumptions. I quote the text from figure 2 of the paper you cited: Figure 2. Bland–Altman plots comparing cFT (right) and RIA (left) against EqD. Mean bias is 0 [95% CI 29.4 to 29.4] for RIA and -19.4% [95% CI 45 to 6.1] for cFT. </p><p>How do we reconcile such information in papers supporting Vermeulen? </p><p></p><p>SHBG and T doesn't seem to have a fixed single affinity, which would make sense (in nature's design). <a href="https://www.ncbi.nlm.nih.gov/pubmed/25308967" target="_blank">Inverse relationship between hSHBG affinity for testosterone and hSHBG concentration revealed by surface plasmon resonance. - PubMed - NCBI</a> </p><p></p><p>The problem is very few studies have actually tried to ask the question on accuracy in the last 40 years!!! Problems with the simple model of Free T calculation are well known that is why people have been developing empiric equations for computing free T. I will try to dig some other refs...</p></blockquote><p></p>
[QUOTE="in_TRT, post: 146646, member: 38777"] The older papers have too many simplistic assumptions. I quote the text from figure 2 of the paper you cited: Figure 2. Bland–Altman plots comparing cFT (right) and RIA (left) against EqD. Mean bias is 0 [95% CI 29.4 to 29.4] for RIA and -19.4% [95% CI 45 to 6.1] for cFT. How do we reconcile such information in papers supporting Vermeulen? SHBG and T doesn't seem to have a fixed single affinity, which would make sense (in nature's design). [URL="https://www.ncbi.nlm.nih.gov/pubmed/25308967"]Inverse relationship between hSHBG affinity for testosterone and hSHBG concentration revealed by surface plasmon resonance. - PubMed - NCBI[/URL] The problem is very few studies have actually tried to ask the question on accuracy in the last 40 years!!! Problems with the simple model of Free T calculation are well known that is why people have been developing empiric equations for computing free T. I will try to dig some other refs... [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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