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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="Cataceous" data-source="post: 145072" data-attributes="member: 38109"><p>Presumably there should be some normal ranges built up for equilibrium dialysis tests. If so then the advantage of TruT would lie in using the same ranges, though the developers of TruT may be working to establish normals. The Vermeulen method is still useful, in that <a href="https://www.researchgate.net/publication/257347511_Free_testosterone_by_direct_and_calculated_measurement_versus_equilibrium_dialysis_in_a_clinical_population" target="_blank">it correlates well</a> with results of equilibrium dialysis. But the absolute numbers don't match.</p><p></p><p>My understanding is that estradiol comes from free T, not total. I don't think the rate of conversion is high enough to change free T independently of SHBG/ALB. That is, as conversion happens more T is released from ALB (fast) and SHBG (slow).</p><p></p><p>In the <a href="https://www.excelmale.com/threads/spreadsheet-for-calculating-free-t-e2.17216/" target="_blank">multi-ligand model</a>, free estradiol is a function of testosterone, total estradiol, SHBG etc. But total estradiol production is in turn mainly a function of free testosterone and aromatase.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 145072, member: 38109"] Presumably there should be some normal ranges built up for equilibrium dialysis tests. If so then the advantage of TruT would lie in using the same ranges, though the developers of TruT may be working to establish normals. The Vermeulen method is still useful, in that [URL='https://www.researchgate.net/publication/257347511_Free_testosterone_by_direct_and_calculated_measurement_versus_equilibrium_dialysis_in_a_clinical_population']it correlates well[/URL] with results of equilibrium dialysis. But the absolute numbers don't match. My understanding is that estradiol comes from free T, not total. I don't think the rate of conversion is high enough to change free T independently of SHBG/ALB. That is, as conversion happens more T is released from ALB (fast) and SHBG (slow). In the [URL='https://www.excelmale.com/threads/spreadsheet-for-calculating-free-t-e2.17216/']multi-ligand model[/URL], free estradiol is a function of testosterone, total estradiol, SHBG etc. But total estradiol production is in turn mainly a function of free testosterone and aromatase. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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