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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="madman" data-source="post: 144980" data-attributes="member: 13851"><p>Schematic Representation of Experimental models of Testosterone Binding to SHGB</p><p></p><p>(a) linear model of testosterone (T) binding to SHBG as conceptualized by Vermeulan, Sodergard and Mazer</p><p></p><p><span style="color: rgb(184, 49, 47)"><strong>(b) new model (ZBJ, schematic adaptation) proposed by Zakharov</strong> </span></p><p></p><p></p><p></p><p>[ATTACH=full]7231[/ATTACH]</p><p>Schematic representation of experimental models of testosterone binding to SHBG. <strong>(a) Linear model of testosterone (T) binding to SHBG as conceptualized by Vermeulen <em>et al.</em> (3), Södergard <em>et al.</em> (4), and Mazer (5).</strong> <strong><span style="color: rgb(184, 49, 47)">(b) New model (ZBJ, schematic adaptation) proposed by Zakharov <em>et al.</em> (34) incorporating the dynamics of allosteric regulation in testosterone binding to SHBG.</span></strong> The different shapes represent conformationally distinct states of SHBG in the dynamic repartitioning of free testosterone into bound forms. <strong><span style="color: rgb(184, 49, 47)">Recent evidence </span>derived from <span style="color: rgb(184, 49, 47)">new biophysical techniques </span>indicates that the<span style="color: rgb(184, 49, 47)"> binding of testosterone to SHBG is a dynamic, multistep process. </span>The binding of <span style="color: rgb(184, 49, 47)">one molecule of testosterone</span> to the <span style="color: rgb(184, 49, 47)">first binding site on an SHBG dimer </span>leads to <span style="color: rgb(184, 49, 47)">conformational rearrangement and allostery </span>between the <span style="color: rgb(184, 49, 47)">two binding sites</span>, such that the <span style="color: rgb(184, 49, 47)">second testosterone molecule binds to the second binding site</span> with a <span style="color: rgb(184, 49, 47)">different binding affinity</span>; there is <span style="color: rgb(184, 49, 47)">readjustment of equilibria</span> between these <span style="color: rgb(184, 49, 47)">interconverting microstates. </span></strong>This multistep, allosteric model provides validated estimates of free testosterone, which have close correspondence with values measured using equilibrium dialysis.</p></blockquote><p></p>
[QUOTE="madman, post: 144980, member: 13851"] Schematic Representation of Experimental models of Testosterone Binding to SHGB (a) linear model of testosterone (T) binding to SHBG as conceptualized by Vermeulan, Sodergard and Mazer [COLOR=rgb(184, 49, 47)][B](b) new model (ZBJ, schematic adaptation) proposed by Zakharov[/B] [/COLOR] [ATTACH=full]7231[/ATTACH] Schematic representation of experimental models of testosterone binding to SHBG. [B](a) Linear model of testosterone (T) binding to SHBG as conceptualized by Vermeulen [I]et al.[/I] (3), Södergard [I]et al.[/I] (4), and Mazer (5).[/B] [B][COLOR=rgb(184, 49, 47)](b) New model (ZBJ, schematic adaptation) proposed by Zakharov [I]et al.[/I] (34) incorporating the dynamics of allosteric regulation in testosterone binding to SHBG.[/COLOR][/B] The different shapes represent conformationally distinct states of SHBG in the dynamic repartitioning of free testosterone into bound forms. [B][COLOR=rgb(184, 49, 47)]Recent evidence [/COLOR]derived from [COLOR=rgb(184, 49, 47)]new biophysical techniques [/COLOR]indicates that the[COLOR=rgb(184, 49, 47)] binding of testosterone to SHBG is a dynamic, multistep process. [/COLOR]The binding of [COLOR=rgb(184, 49, 47)]one molecule of testosterone[/COLOR] to the [COLOR=rgb(184, 49, 47)]first binding site on an SHBG dimer [/COLOR]leads to [COLOR=rgb(184, 49, 47)]conformational rearrangement and allostery [/COLOR]between the [COLOR=rgb(184, 49, 47)]two binding sites[/COLOR], such that the [COLOR=rgb(184, 49, 47)]second testosterone molecule binds to the second binding site[/COLOR] with a [COLOR=rgb(184, 49, 47)]different binding affinity[/COLOR]; there is [COLOR=rgb(184, 49, 47)]readjustment of equilibria[/COLOR] between these [COLOR=rgb(184, 49, 47)]interconverting microstates. [/COLOR][/B]This multistep, allosteric model provides validated estimates of free testosterone, which have close correspondence with values measured using equilibrium dialysis. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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