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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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<blockquote data-quote="madman" data-source="post: 144921" data-attributes="member: 13851"><p>Two important points to keep in mind- <strong>T:SHBG <span style="color: rgb(184, 49, 47)">(binding)</span></strong></p><p></p><p></p><p></p><p></p><p><strong>Improved TruT Companion Diagnostics</strong></p><p></p><p><strong>*Based on the fundamental discovery of testosterone partitioning, our team has developed an accurate free testosterone determination method.</strong> <strong>While examining the mechanistic origin of this systematic inaccuracy in free testosterone values using the linear model of SHBG:testosterone association, <span style="color: rgb(184, 49, 47)">we discovered that the SHBG dimer exhibits conformational allostery in binding testosterone. Our TruT™ companion diagnostic, incorporating the correct parameters and non-linear dynamics in T:SHBG association has resulted in a framework for accurate determination of free testosterone values.</span></strong></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">TruT</span></strong></p><p><strong>*This algorithm is based on experimental data demonstrating that testosterone’s binding to SHBG is a multi-step process involving an allosteric interaction between the two binding sites on the SHBG dimer. </strong></p></blockquote><p></p>
[QUOTE="madman, post: 144921, member: 13851"] Two important points to keep in mind- [B]T:SHBG [COLOR=rgb(184, 49, 47)](binding)[/COLOR][/B] [B]Improved TruT Companion Diagnostics[/B] [B]*Based on the fundamental discovery of testosterone partitioning, our team has developed an accurate free testosterone determination method.[/B] [B]While examining the mechanistic origin of this systematic inaccuracy in free testosterone values using the linear model of SHBG:testosterone association, [COLOR=rgb(184, 49, 47)]we discovered that the SHBG dimer exhibits conformational allostery in binding testosterone. Our TruT™ companion diagnostic, incorporating the correct parameters and non-linear dynamics in T:SHBG association has resulted in a framework for accurate determination of free testosterone values.[/COLOR][/B] [B][COLOR=rgb(184, 49, 47)]TruT[/COLOR] *This algorithm is based on experimental data demonstrating that testosterone’s binding to SHBG is a multi-step process involving an allosteric interaction between the two binding sites on the SHBG dimer. [/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Calculate Free Testosterone with TruT by FPT
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