1. #1

    T3 & Total Testosterone

    Dear All,

    Over the last six months I added T3 supplementation to my TRT protocol, which is as follows:

    Testosterone Cypionate: 110 mg per week (35mg + 35 mg + 40 mg)
    HCG: 600 IU per week (200+200+200)

    Before adding T3 to my protocol, my Total Testosterone was consistently in the 1000-1200 range. However with the addition of T3 (Cytomel 20mg per day) my Total Testosterone has decreased to below the 1000 ng/dL threshold. Specifically the most recent measurements were:

    980 (9/2016), 978 (11/2016), 980 (1/2017) and 823 (2/2017). The thyroid values in this latest blood work came back quite elevated:

    Free T4: 3.1 [0.8-1.7]
    Free T3: 8.3 [2.0-4.4]
    T3 Uptake: 46 [27-41%]
    Reverse T3: 43 [9.2-24.1]

    It seems to me that in my case T3 supplementation has led to a decrease of Total Testosterone. Is my conclusion reasonable? Can indeed T3 supplementation cause a reduction in Total Testosterone? ....particularly in my case where it seems that my endocrinologist may have perhaps overdosed T3. Otherwise I do not quite understand what could have caused a reduction in my Total T, given that apart from T3, my TRT protocol has remained unchanged.

    Thank you for your help.

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  3. #2
    Quote Originally Posted by Gokk View Post
    Dear All,

    Over the last six months I added T3 supplementation to my TRT protocol, which is as follows:

    Testosterone Cypionate: 110 mg per week (35mg + 35 mg + 40 mg)
    HCG: 600 IU per week (200+200+200)

    Before adding T3 to my protocol, my Total Testosterone was consistently in the 1000-1200 range. However with the addition of T3 (Cytomel 20mg per day) my Total Testosterone has decreased to below the 1000 ng/dL threshold. Specifically the most recent measurements were:

    980 (9/2016), 978 (11/2016), 980 (1/2017) and 823 (2/2017). The thyroid values in this latest blood work came back quite elevated:

    Free T4: 3.1 [0.8-1.7]
    Free T3: 8.3 [2.0-4.4]
    T3 Uptake: 46 [27-41%]
    Reverse T3: 43 [9.2-24.1]

    It seems to me that in my case T3 supplementation has led to a decrease of Total Testosterone. Is my conclusion reasonable? Can indeed T3 supplementation cause a reduction in Total Testosterone? ....particularly in my case where it seems that my endocrinologist may have perhaps overdosed T3. Otherwise I do not quite understand what could have caused a reduction in my Total T, given that apart from T3, my TRT protocol has remained unchanged.

    Thank you for your help.
    If you lower your T3 dose to get it where it should be withing the range and also note your TT goes back up, more support for the connection. As it is, your well outside the T4/t3 ranges and that's what I'd focus on first, then see what the T levels do in response.

    - Will @ BrinkZone.com

  4. #3
    Curious how you feel with thyroid levels that high. Do you have hyperthyroid symptoms?

  5. #4
    Do you mean 20mcg per day? 20mg of T3 would be an insanely high dose.

    Why did you add T3 to your TRT protocol?

    Id worry less about a slight drop in total T and instead focus on how you feel. Do you feel ok?


    Quote Originally Posted by Gokk View Post
    Dear All,

    Over the last six months I added T3 supplementation to my TRT protocol, which is as follows:

    Testosterone Cypionate: 110 mg per week (35mg + 35 mg + 40 mg)
    HCG: 600 IU per week (200+200+200)

    Before adding T3 to my protocol, my Total Testosterone was consistently in the 1000-1200 range. However with the addition of T3 (Cytomel 20mg per day) my Total Testosterone has decreased to below the 1000 ng/dL threshold. Specifically the most recent measurements were:

    980 (9/2016), 978 (11/2016), 980 (1/2017) and 823 (2/2017). The thyroid values in this latest blood work came back quite elevated:

    Free T4: 3.1 [0.8-1.7]
    Free T3: 8.3 [2.0-4.4]
    T3 Uptake: 46 [27-41%]
    Reverse T3: 43 [9.2-24.1]

    It seems to me that in my case T3 supplementation has led to a decrease of Total Testosterone. Is my conclusion reasonable? Can indeed T3 supplementation cause a reduction in Total Testosterone? ....particularly in my case where it seems that my endocrinologist may have perhaps overdosed T3. Otherwise I do not quite understand what could have caused a reduction in my Total T, given that apart from T3, my TRT protocol has remained unchanged.

    Thank you for your help.

  6. #5
    Hi Gokk

    Why the T3 to your TRT+HCG protocol? Your thyroid seems to be functioning well.

    I have really low T4 and low TSH (doc only put me on 50mg T4 daily) and recently switched to HCG-mono therapy (5th week now) and have yet to run new bloodwork (scheduled in another 3 weeks' time).

    Would love to find out more about the effects and rationale from you. Thanks!

  7. #6
    Sorry...Indeed I meant 20 mcg. I actually feel fine....which is strange, because at these levels of FT4, FT3 etc. I should experience some symptoms of Hyperthyroidism....but in fact this is not at all the case...

  8. #7
    I added T3 becuse my levels were borderline low...so I thought I could get some benefits from T3 supplementation. It turned out that it did not make any meaningful difference...

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