I use DHEA troches and have no E2 problems with it. I don't think my E2 level changed at all. I tried the DHEA micronized lipid matrix but had no change in DHEA level. DHEA troches put my DHEA way up over range at 25mg twice a day. I cut down to 12mg twice a day to get to top of range. Cutting a 100mg DHEA troche into 8 can be done and that makes it very inexpensive.