Generally, Doctors who advocate TRT seem to subscribe to the theory of Androgen Receptor (AR) suturation. Under this theory, the ARs in the prostate are fully saturated at total testosterone levels of 150. And thus, a testosterone level 1,200 is no more likely to cause malignant or benign prostate growth than is a testosterone level of 200.
Testosterone and DHT bind to the same AR. So, one would think that if the AR is saturated such that increased T levels aren't a concern for prostate cancer (PC) then increased DHT levels wouldn't be a concern for PC either. However, the same doctors who believe in the saturation theory, still seem concerned with elevated DHT causing or worsening prostate issues. Why is this?
hoping dr Crisler or Saya or McClain could shed light. Nelson
Testosterone and DHT bind to the same AR. So, one would think that if the AR is saturated such that increased T levels aren't a concern for prostate cancer (PC) then increased DHT levels wouldn't be a concern for PC either. However, the same doctors who believe in the saturation theory, still seem concerned with elevated DHT causing or worsening prostate issues. Why is this?
hoping dr Crisler or Saya or McClain could shed light. Nelson
