1. #1

    Most common total weekly dose for cypionate/enanthate

    I wanted to get some feedback from members on what dosage range is the most widely used.
    60-80mg
    80-100mg
    100-120mg
    120mg and up
    Not concerned with the frequency, just the total 7 day amount.

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  3. #2
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    My first T cyp protocol called for 150/wk after 8 weeks my TT trough was 1175, FT 33 E2 29 HCT 51.7
    I am now trying 120 and don't plan on doing bloods for 3 months unless I feel weird or something makes me want to look.

    I crashed my ferritin from being too curious and chasing numbers NO MORE.

  4. #3
    SHBG determines dosage, 80-100mg weekly. Are you already thinking about going back on TRT?

  5. #4
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    Quote Originally Posted by sh1973 View Post
    I wanted to get some feedback from members on what dosage range is the most widely used.
    60-80mg
    80-100mg
    100-120mg
    120mg and up
    Not concerned with the frequency, just the total 7 day amount.
    I use 100mg total so I don't know which of your groups to choose.

  6. #5
    Yes, Defy recommends going back on. After using a hefty dose of clomid for 36 days my LH was only .3. This reflects strong secondary hypogonadism. The last week of clomid was 50mg per day. No need in continuing as per Defy.

  7. #6
    At 150mg/wk I was over the 1500 TT range from labcorb at trough.

    Dosage has been reduced twice since then, now on 96mg/wk, in part due to high HCT and low ferritin so it would not be good for me to donate blood.

    We'll see...

  8. #7
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    Quote Originally Posted by FeelingLost View Post

    I crashed my ferritin from being too curious and chasing numbers NO MORE.
    How did you crash ferritin by chasing? From doing too many blood draws for labs?

  9. #8
    I agree 100% with feelinglost. I am surprise on how well i am feeling on 110mg/week of testosterone cypionate. I was able to stop using anastrozole and hopefully my HCT will get under control. Problem with chasing high trough numbers is that you will be 100% of the time on supra physiological levels and that can bring a lot of issues with it (high e2, high hct, etc).
    I am starting to believe that lower dosages are the way to go. If you can control side effects by reducing dosage and you still feel good why chase numbers?
    I thought i would only feel good at over 1000 TT and I am surprised how well i feel at 110mg a week (not sure what my TT is but i guess 650-700 area. Not sure if this is because I dropped anastrozole. But all I can say I am feeling just fine at a lower dosage. And hopefully that will take care of HCT.

  10. #9
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    Quote Originally Posted by LakeGuy81 View Post
    How did you crash ferritin by chasing? From doing too many blood draws for labs?
    Yes and blood donations. When I first started learning about TRT peeps were scaring the shit out of me every time I posted a HCT over 50.
    So I donated blood almost every 2 months. Every blood test some only 5-6 weeks apart they drew 10-12 vials because I asked for more tests than required.

    I live at 6000 ft above sea lvl, I play hard at 8000' and my pre TRT HCT is 49.
    It took me a little while to learn that not everyone that posts on forums knows what they are talking about.

  11. #10
    Quote Originally Posted by FeelingLost View Post
    It took me a little while to learn that not everyone that posts on forums knows what they are talking about.
    Spending time on the PeakT forums? (joke...yes it happens here too)

  12. #11
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    Quote Originally Posted by sh1973 View Post
    I wanted to get some feedback from members on what dosage range is the most widely used.
    60-80mg
    80-100mg
    100-120mg
    120mg and up
    Not concerned with the frequency, just the total 7 day amount.

    It is always best to start low and go slow.

    100 mg/week is a common starting dose albeit low for some.

    The purpose of trt is to relieve symptoms of low testosterone -low energy/fatigue,low libido/ed issues,negative effects on mood (depression/anxiety/irratability/anger/lack of drive), body composition changes (loss of muscle/increase adipose).

    Whether that requires having ones testosterone levels (trough) to be in the mid-normal or high/normal physiological range.

    Some men need to only be in the mid/normal physiological range to experience relief of low t symptoms where as others feel better in the high/normal range.

    As far as doses some can only reach mid/normal on 100 mg/week and others can reach high/normal on same dose.

    On average I would say 100-150 mg/week is what is required to attain healthy levels mind you 150 mg/week can be too much for some and of course there are some that need 200 mg/week (minority).

  13. #12
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    I am currently at this dosage after 1 year of TRT and after making many adjustments.
    68 mg a week (34 mg split into 2 injections a week).
    200 IU's HCG every Monday, Wed, Friday.
    .25 mg Anastrozole a week split at .125 compounded taken at time of injection.
    25mg Losartan daily.

    I have donated blood every 2 months since May of 2017 and for the first time My Hematocrit and Hemo have stabilized and I have not donated for 3 months. Ferritin was crashing and now its back to 63. Not sure if it was the reduction in HCG from 300 IU's to 200 IU's 3x weekly, taking 25 mg of Losartan the last 6 months or my body has made adjustments?

    As Madman said start low and go slow. For myself I clearly require alot less dosages then most and still achieve TT 900+ in my trough and almost 1100 peaks. SHBG has also dropped from 48 to 35 so everything has finally moved into a spot that looks good on labwork.

  14. #13
    Moderator Vince's Avatar
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    This was my starting protocol back on December 4th 2014,
    I was injecting T cyp twice a week 70mg x 2 and 500iu of Hcg x 2 a week.
    I am not a medical practitioner. Any suggestions I provide are not medical recommendations and are just my opinions. Please consult with your physician on any matters concerning your health.

  15. #14
    Vince, where are you now as far as dose?

  16. #15
    most people are close to 100 mg per week, thats a good starting point. its really down to blood tests though, the problem is someone injecting 80 mg per week could have the same levels as the next guy injecting 200 mg per week. Not usually the case, but it can happen.

  17. #16
    Thanks for all the replies. I have a very difficult case. I recently came completely off everything after 8 years, but unfortunately had no pituitary response to Clomid. Iím working with my urologist and Defy to sort this out. Defy advises me to discontinue clomid and restart TRT. Iíve started back at 80mg per week 40x2. My problem all along has been absolutely no libido on trt. I have very high shbg, usually 50-70 range. Large doses have never worked. I realize this is common thinking regarding elevated shbg, but has never held true with me. I feel ok now at 80mg but again have no libido and canít perform without cialis. I spent several years at 100mg per week once e7d. I had no ED at this dose and very little libido. Iíve tried doses all the way up to 200mg per week but the high doses make me feel terrible. 100 mg puts me 850-900ng day seven, 80mg 700-725ng day seven, 120mg 1000-1025ng day 7. All these are once weekly doses. Probably felt the best at 120mg as far as energy but this dose increased hematocrit too much. Defy wants me to do twice weekly dosing and Iím going to give it a try, but I think Iím going to have to raise the dose some. I donít do well with hcg at any dose and can only take dhea at 10mg daily, also cannot tolerate pregnenolone at any dose. Iím hopeful between Defy and my urologist that we can figure something out. Iíve never at any dose had any problems with E2, in fact itís normally 20-25 sensitive assay no matter what the dose. I figure Iíve wasted eight years of my life trying to figure this out so another year to isnít going to hurt anything.

  18. #17
    Moderator Vince's Avatar
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    Quote Originally Posted by sh1973 View Post
    Vince, where are you now as far as dose?
    16 mg of testosterone cypionate daily and 500 IU of HCG twice a week.
    I am not a medical practitioner. Any suggestions I provide are not medical recommendations and are just my opinions. Please consult with your physician on any matters concerning your health.

  19. #18
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    Quote Originally Posted by sh1973 View Post
    Thanks for all the replies. I have a very difficult case. I recently came completely off everything after 8 years, but unfortunately had no pituitary response to Clomid. I’m working with my urologist and Defy to sort this out. Defy advises me to discontinue clomid and restart TRT. I’ve started back at 80mg per week 40x2. My problem all along has been absolutely no libido on trt. I have very high shbg, usually 50-70 range. Large doses have never worked. I realize this is common thinking regarding elevated shbg, but has never held true with me. I feel ok now at 80mg but again have no libido and can’t perform without cialis. I spent several years at 100mg per week once e7d. I had no ED at this dose and very little libido. I’ve tried doses all the way up to 200mg per week but the high doses make me feel terrible. 100 mg puts me 850-900ng day seven, 80mg 700-725ng day seven, 120mg 1000-1025ng day 7. All these are once weekly doses. Probably felt the best at 120mg as far as energy but this dose increased hematocrit too much. Defy wants me to do twice weekly dosing and I’m going to give it a try, but I think I’m going to have to raise the dose some. I don’t do well with hcg at any dose and can only take dhea at 10mg daily, also cannot tolerate pregnenolone at any dose. I’m hopeful between Defy and my urologist that we can figure something out. I’ve never at any dose had any problems with E2, in fact it’s normally 20-25 sensitive assay no matter what the dose. I figure I’ve wasted eight years of my life trying to figure this out so another year to isn’t going to hurt anything.
    Many of us can't perform without ED drugs. TRT does not always fix that.
    High doses of T cyp did send my libido thru the roof but I still could not get or keep an erection without cialas. That is it's own kind of hell trust me.
    900 on day 7 is the most I would eve want. I would look else where after getting my T lvl stabilized. What other drugs and supplements are you taking? Are you diabetic? How about your blood pressure? Both can kill stiffies.

    I have found low dose cialas and Bupropion Hydro helps my libido, erections and intensity of climax.

  20. #19
    No other medications or Heath concerns. Take a daily multi, 1000mcg b-12, 4000iu D3, 250mg magnesium, dhea 10mg and 3000mg high quality fish oil. At 100mg weekly I had zero issues with ED. No high BP, diabetic or anything like that. Pretty thin and workout 5-6 times weekly, mostly cardio and use bow flex twice weekly. Donít smoke, rarely drink and eat very healthy.

  21. #20
    I'm in a similar boat. High SHBG. No ED whatsoever, but libido is not really there.

    2-25-18 labs were while on this protocol:
    Test- 110mg split into EOD dosing
    HCG - 800IU split into EOD dosing
    No AI

    I inject test and HCG same day in the morning. Labs drawn in the morning of injection day, prior to injections.


    Total 1687 (250-1100 ng/dL)
    Free 238.6 (46.0-224.0)
    Bioavailable 459.6 (110.0-575.0 ng/dL)
    SHBG 47 (10-50)
    E2 Sensitive - 73
    E2 standard - 59



  22. #21
    Thatís some really high levels. I feel terrible with levels that high.

  23. #22
    80 to 120 is most common. I think 80 to 100 is best, but everyone is a bit different. IMO, issues that people complain of most often, such as fighting E2 and low Ferritin, are due to too high of a T dose.

  24. #23
    Do you? I appreciate your input. I'll take what you say into consideration more than most simply because you're a high SHBG man like myself. It's easy for low- normal SHBG men to say that my total T is high, but coming from another high SHBG guy, your anecdotal experience that high levels like this make you feel terrible holds a little more weight for me.

    What do you like your free testosterone levels to be around?

  25. #24
    Gman I seem to feel best in the 12-18ng range. Iíve had it as high as 45ng. For me it literally feels like I have the flu once I pass 22-25ng free t. I might add as well E2 was not out of range whenever I felt like this. One thing I learned the hard way is guys like us should never take Aimidex. It will knock your estrogen to the floor in a hurry even with a very small dose it took me 4 to 5 weeks to get over trying that once. Even with total t levels 1000-1200ng Iím only 24-26pg/ml on the sensitive E2 assay.

  26. #25
    What was the range on your blood tests for free T? I use questdiagnostics and their range is pretty different.

    And thatís funny you say that about arimidex. My E2 crashes with even a tiny amount too! Same thing with exemestane. Verified by two different blood tests months apart. 0.25mg EOD of arimidex, and 6.25mg EOD of exemestane both had my sensitive E2 at 9.

    Got any other tips for a high SHBG guy like myself? Id much rather learn from others mistakes than to have to make them myself lol

  27. #26
    The range is 9-30. Someone like you or I does not need to take anything to lower estrogen since most of it is bound up anyhow from the high shbg. I honestly feel some better when eating soy or having a drink occasionally, both of which increase estrogen in the body. I just canít seem to get the libido aspect conquered. Lots of people swear by hcg, but it does nothing for me. I donít care about testicle atrophy, due to having a vasectomy. I just want to feel decent and have a normal libido. I always do pretty well energy wise and with mood. I have found also that cutting back on cardio has lowered my shbg some. I used to do 6-7 days a week at 30-40 minutes, but now do 4-5 days at 30min. Iíve just started with the twice weekly dosing, so Iíll have to see how it pans out. The doc at Defy says they see a reduction in hematocrit by splitting the dose. My hematocrit doesnít get too bad until I go above 120mg per week.

  28. #27
    So is there any other ways you’ve found to lower your SHBG. Has the once per week injections gotten it down at all? I’m currently on EOD, to minimize spikes and reduce E2 as well as HCT. I’m obv aware that less frequent injections can lower SHBG a bit, but not sure if anectodal stories of this hold true or not. I’d hate to go to once a week, or even twice weekly, have my HCT and E2 spike more, and not even get the benefit of lowered SHBG.

    Also I apologize if this is interrupting the original question of this post. I should probably message you directly. I have so many questions I can think to ask u lol.

  29. #28
    You can pm if u want

  30. #29
    Quote Originally Posted by sh1973 View Post
    You can pm if u want
    sh1973 and Gman86 - I also have high SHBG and don't tolerate Ai's too well. What're the implications of this?


  31. #30
    You can actually end up causing osteoporosis if youíre not careful. Nelson discusses this in some of his podcasts.

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