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For those with either NAFLD/NASH or high lipids (trigylcerides, ldl, etc), a drug called mgl-3196 by Madrigal Pharm. just concluded its phase 2 trial and patients had an average of their SHBG increasing 80% from baseline with some over 100%. Drug also statistically significantly lowered...

Rdw 17.2 ref range 12.3-15.4 RBC 6.33 ref range 4.14-5.8 MCV 78 ref range 79-97 MCH 26.4 ref range 26.6-33 Thoughts? I have fatigue and shortness of breath. On Trt - 160mg divided into 2 doses a week.What should I get checked? Iron? Ferritin? Thanks

Im a low SHBG guy (usually single digits). Do you have muscle loss/weakness? Fasciculations (muscle twitching)? Raised triglycerides? Heat intolerance? Abdominal weight gain? Shortness of Breath? Exercise intolerance? Any other symptoms?

Been with Defy for awhile and have nothing but good things to say about them. Besides some cognitive benefits of not having low T, I dont feel a whole lot of from TRT. TRT protocol is 160 mg a week split in two doses and HCG. I used to be a 5-6 day a week gym guy and was in very good shape...

I'm quite positive I'm insulin resistant with an out of range low SHBG and I'm looking into metformin. TRT so far hasn't been anywhere near effective as I thought it'd be and I am realizing that it is most likely (hopefully) because of the low SHBG and insulin resistance.

Hey everyone, new to the forum. Late 20s male, 3 weeks into trt with Defy and Dr Saya. On a 160mg a week twice a week and Hcg 350 mg 2x a week. So far haven't really noticed anything but wasn't really expecting to. A couple years ago started feeling awful and have had a host of symptoms. I...