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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Why didn't my levels change much despite a dose imcrease?
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<blockquote data-quote="Cataceous" data-source="post: 254374" data-attributes="member: 38109"><p>Total testosterone basically doubled, which is about right when the dose is doubled and SHBG doesn't change. The free testosterone tests are probably immunoassay-based, which renders them nearly useless. Free testosterone is also expected to double in this situation.</p><p></p><p>More generally, think of free testosterone as the main driver of your benefits. Total testosterone includes testosterone in "storage". Think of SHBG and albumin as the storage. More SHBG allows more storage and more total testosterone. But this is pretty independent of free testosterone, which is driven directly by the TRT dose:</p><p></p><p>TRT dose -> sets free testosterone -> sets total testosterone also as function of SHBG</p><p></p><p>If you play with a free testosterone calculator and hold free testosterone constant then you'll quickly see that raising SHBG increases total testosterone, while lowering SHBG decreases total testosterone.</p><p></p><p>A lot of the conventional wisdom about SHBG is misguided or just wrong. It's fair to suspect that high or low levels may cause some problems, but these don't directly relate to free testosterone and the details have not been nailed down. For example, there's speculation that low SHBG leads to reduced androgen signaling, without a concurrent reduction in estrogen signaling. In this hypothesis it is the signaling imbalance that leads to symptoms and difficulty dialing in TRT.</p><p></p><p>As for factors affecting SHBG, androgens tend to decrease it while estrogens tend to increase it.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 254374, member: 38109"] Total testosterone basically doubled, which is about right when the dose is doubled and SHBG doesn't change. The free testosterone tests are probably immunoassay-based, which renders them nearly useless. Free testosterone is also expected to double in this situation. More generally, think of free testosterone as the main driver of your benefits. Total testosterone includes testosterone in "storage". Think of SHBG and albumin as the storage. More SHBG allows more storage and more total testosterone. But this is pretty independent of free testosterone, which is driven directly by the TRT dose: TRT dose -> sets free testosterone -> sets total testosterone also as function of SHBG If you play with a free testosterone calculator and hold free testosterone constant then you'll quickly see that raising SHBG increases total testosterone, while lowering SHBG decreases total testosterone. A lot of the conventional wisdom about SHBG is misguided or just wrong. It's fair to suspect that high or low levels may cause some problems, but these don't directly relate to free testosterone and the details have not been nailed down. For example, there's speculation that low SHBG leads to reduced androgen signaling, without a concurrent reduction in estrogen signaling. In this hypothesis it is the signaling imbalance that leads to symptoms and difficulty dialing in TRT. As for factors affecting SHBG, androgens tend to decrease it while estrogens tend to increase it. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Why didn't my levels change much despite a dose imcrease?
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