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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is the Function of Sex Hormone Binding Globulin SHBG?
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<blockquote data-quote="Nelson Vergel" data-source="post: 178216" data-attributes="member: 3"><p style="text-align: center"><strong><span style="font-size: 18px">Causes of Low and High SHBG</span></strong></p> <p style="text-align: center">[ATTACH=full]9739[/ATTACH]</p><p></p><p><span style="font-size: 18px"><strong>Circulating SHBG level as a biomarker of metabolic risk</strong></span></p><p>In epidemiologic studies, low total testosterone levels have been associated with increased risks of diabetes and metabolic syndrome, a cluster of conditions including hypertension, insulin resistance, central obesity, and dyslipidemia, which predispose individuals to an increased risk of cardiovascular disease. In longitudinal analyses, SHBG levels rather than total or free testosterone levels have been independently and prospectively associated with incident diabetes and metabolic syndrome after adjustments for age, adiposity, and comorbid conditions (<a href="https://www.excelmale.com/forum/javascript%3A;" target="_blank">97</a>, <a href="https://www.excelmale.com/forum/javascript%3A;" target="_blank">98</a>). Among children and adolescents, SHBG may also be a biomarker for metabolic syndrome risk (<a href="https://www.excelmale.com/forum/javascript%3A;" target="_blank">99</a>), and lower levels were more robustly associated with the risk of metabolic syndrome in boys than in girls (<a href="https://www.excelmale.com/forum/javascript%3A;" target="_blank">100</a>). We do not know whether SHBG is merely a marker of metabolic risk or whether SHBG plays a causal role in the pathophysiology of metabolic disorders such as diabetes and metabolic syndrome.</p><p></p><p>Source: <a href="https://academic.oup.com/edrv/article/38/4/302/3897170" target="_blank">Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 178216, member: 3"] [CENTER][B][SIZE=18px]Causes of Low and High SHBG[/SIZE][/B] [ATTACH type="full" alt="low and high SHBG causes.jpg"]9739[/ATTACH][/CENTER] [SIZE=18px][B]Circulating SHBG level as a biomarker of metabolic risk[/B][/SIZE] In epidemiologic studies, low total testosterone levels have been associated with increased risks of diabetes and metabolic syndrome, a cluster of conditions including hypertension, insulin resistance, central obesity, and dyslipidemia, which predispose individuals to an increased risk of cardiovascular disease. In longitudinal analyses, SHBG levels rather than total or free testosterone levels have been independently and prospectively associated with incident diabetes and metabolic syndrome after adjustments for age, adiposity, and comorbid conditions ([URL='https://www.excelmale.com/forum/javascript%3A;']97[/URL], [URL='https://www.excelmale.com/forum/javascript%3A;']98[/URL]). Among children and adolescents, SHBG may also be a biomarker for metabolic syndrome risk ([URL='https://www.excelmale.com/forum/javascript%3A;']99[/URL]), and lower levels were more robustly associated with the risk of metabolic syndrome in boys than in girls ([URL='https://www.excelmale.com/forum/javascript%3A;']100[/URL]). We do not know whether SHBG is merely a marker of metabolic risk or whether SHBG plays a causal role in the pathophysiology of metabolic disorders such as diabetes and metabolic syndrome. Source: [URL='https://academic.oup.com/edrv/article/38/4/302/3897170']Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
What is the Function of Sex Hormone Binding Globulin SHBG?
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