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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Tips on how to blend propionate with enanthate (or cypionate)?
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<blockquote data-quote="Cataceous" data-source="post: 201703" data-attributes="member: 38109"><p>I've only tried the Ultra-Spec vials. Judging by the description the ALK vials should also be fine.</p><p></p><p>Regarding the ester ratio selection, ideally it is informed by one's particular response to propionate. I've found it convenient to characterize this response in terms of variation above and below the mean serum testosterone level. It's basically a function of the apparent half-life. Although my propionate measurements were a bit noisy, I averaged them to estimate that I see a variation of +/-50% about the mean when using only propionate. As it happens this agrees pretty well with the nominal half-life of 0.8 days that's often given for propionate. The mean serum level is estimated through the previously measured response to frequent injections of a longer ester. For example, daily cypionate injections are assumed to give no variation in serum levels. This isn't strictly true, but the variation is small enough to be ignored.</p><p></p><p>With these assumptions the daily variation in serum testosterone seen with a mix of propionate and a longer ester is simply the fraction of the testosterone provided by propionate multiplied by 50%. Looking at the diurnal testosterone curves for young men I picked +/-25% as a reasonable high end for observed natural variation. Imitating this requires that half the testosterone in a blend be provided by propionate. I was originally drawing esters separately into the same syringe with a resolution of 0.005 mL. This restriction and the ester concentrations explain the quirk of the 4:3 ratio, which computes to a serum variation of +/-23% instead of 25%.</p><p></p><p>Your sample calculation looks right to me. The ratio of the ester T weights (TP/TC) is 1.2. So 20% more T in propionate should not be ignored in the final calculation.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 201703, member: 38109"] I've only tried the Ultra-Spec vials. Judging by the description the ALK vials should also be fine. Regarding the ester ratio selection, ideally it is informed by one's particular response to propionate. I've found it convenient to characterize this response in terms of variation above and below the mean serum testosterone level. It's basically a function of the apparent half-life. Although my propionate measurements were a bit noisy, I averaged them to estimate that I see a variation of +/-50% about the mean when using only propionate. As it happens this agrees pretty well with the nominal half-life of 0.8 days that's often given for propionate. The mean serum level is estimated through the previously measured response to frequent injections of a longer ester. For example, daily cypionate injections are assumed to give no variation in serum levels. This isn't strictly true, but the variation is small enough to be ignored. With these assumptions the daily variation in serum testosterone seen with a mix of propionate and a longer ester is simply the fraction of the testosterone provided by propionate multiplied by 50%. Looking at the diurnal testosterone curves for young men I picked +/-25% as a reasonable high end for observed natural variation. Imitating this requires that half the testosterone in a blend be provided by propionate. I was originally drawing esters separately into the same syringe with a resolution of 0.005 mL. This restriction and the ester concentrations explain the quirk of the 4:3 ratio, which computes to a serum variation of +/-23% instead of 25%. Your sample calculation looks right to me. The ratio of the ester T weights (TP/TC) is 1.2. So 20% more T in propionate should not be ignored in the final calculation. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Tips on how to blend propionate with enanthate (or cypionate)?
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