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Thoughts on David Sinclair research
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<blockquote data-quote="FunkOdyssey" data-source="post: 230113" data-attributes="member: 44064"><p>I don't think they are on TRT but why would they be if they weren't hypogonadal? Did Huberman explain why he stopped? As far as I know, the only reason he started was to develop some firsthand experience for a book he is writing on hormone optimization.</p><p></p><p></p><p></p><p>To the extent that TRT increases GH and IGF-1, that would be a negative effect among a mix of positive and negative effects of TRT on longevity. And what makes you think TRT shortens telomeres in human men? Some researchers are suggesting testosterone supplementation for the express purpose of lengthening telomeres:</p><p></p><p>[URL unfurl="true"]https://academic.oup.com/jcem/article/101/3/1299/2804951?login=false[/URL]</p><p></p><p></p><p></p><p></p><p>The effects on mouse lifespan are variable but always positive and in some cases very impressive:</p><p></p><p>[URL unfurl="true"]https://link.springer.com/article/10.1007/s11357-020-00274-1[/URL]</p><p>[ATTACH=full]24563[/ATTACH]</p><p></p><p>Peter pushes the envelope of rapamycin dosing and that's why he has the mouth ulcers. I experimented with it at 5 mg weekly and had no trouble with that, although it did make my thumb twitch. It's like TRT or anything else where you can titrate dose to prevent side effects.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 230113, member: 44064"] I don't think they are on TRT but why would they be if they weren't hypogonadal? Did Huberman explain why he stopped? As far as I know, the only reason he started was to develop some firsthand experience for a book he is writing on hormone optimization. To the extent that TRT increases GH and IGF-1, that would be a negative effect among a mix of positive and negative effects of TRT on longevity. And what makes you think TRT shortens telomeres in human men? Some researchers are suggesting testosterone supplementation for the express purpose of lengthening telomeres: [URL unfurl="true"]https://academic.oup.com/jcem/article/101/3/1299/2804951?login=false[/URL] The effects on mouse lifespan are variable but always positive and in some cases very impressive: [URL unfurl="true"]https://link.springer.com/article/10.1007/s11357-020-00274-1[/URL] [ATTACH type="full" alt="rapamycin mouse lifespan.png"]24563[/ATTACH] Peter pushes the envelope of rapamycin dosing and that's why he has the mouth ulcers. I experimented with it at 5 mg weekly and had no trouble with that, although it did make my thumb twitch. It's like TRT or anything else where you can titrate dose to prevent side effects. [/QUOTE]
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Thoughts on David Sinclair research
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