ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The TSH Reference Range Wars: What's "Normal?", Who is Wrong, Who is Right...
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 54255" data-attributes="member: 3"><p>Thyroid. 2016 Nov 3. [Epub ahead of print]</p><p></p><p><strong>The association between changes in thyroid hormones and incident type 2 diabetes: A 7-year longitudinal study.</strong></p><p></p><p>Jun JE1, Jin SM2, Bae JC3, Jee JH4, Hur KY5, Lee MK6, Kim TH7, Kim SW8,9, Kim JH10.</p><p></p><p></p><p></p><p>Abstract</p><p>BACKGROUND:</p><p>Thyroid hormones are important regulators of glucose homeostasis; however, the association between thyroid hormones within the reference range and type 2 diabetes remains unclear. The aim of this study was to clarify the incidence of type 2 diabetes according to the baseline levels and changes of thyroid stimulating hormone (TSH) and thyroid hormones (free thyroxine [FT4] and triiodothyronine [T3]) in euthyroid subjects.</p><p></p><p>METHODS:</p><p>Among the participants who consecutively underwent thyroid function tests between 2006 and 2012 through a yearly health check-up program, 6,235 euthyroid subjects (3,619 men and 2,616 women) without diabetes were enrolled in the study. The change in each hormone was calculated by subtracting the baseline value from the level at the end of follow-up or 1 year before the diagnosis of diabetes.</p><p></p><p>RESULTS:</p><p>During 25,692 person-years of follow-up, there were 229 new cases of type 2 diabetes. After full adjustment for potential confounders including HbA1c and fasting glucose in Cox proportional hazards models,<strong> the individuals in the highest tertile of TSH change (2.5 to 4.2IU/mL) had a greater risk of incident type 2 diabetes (hazard ratio</strong></p><hr /><p><strong>=1.44, 95% confidence interval [CI]: 1.04 - 1.98, p for trend = 0.027) in comparison with individuals in the lowest tertile (-4.1 to -0.5 IU/mL). Simultaneously, the highest tertile of T3 change (16.3 to 104.7 ng/dL) and FT4 change (0.2 to 1.6 ng/dL) conferred protective effects against diabetes (HR = 0.60, 95% CI: 0.43-0.85, p for trend = 0.002 and HR = 0.34, 95% CI: 0.24 - 0.48, p for trend < 0.001, respectively) compared to those in the lowest tertile (-76.5 to -1.8 ng/dL and -0.6 to 0.0 ng/dL, respectively). These associations remained significant when each of the hormones was analyzed as a continuous variable. However, baseline levels or tertiles of TSH and thyroid hormones were not associated with the risk of diabetes.</strong></p><p></p><hr /><p></p><p>CONCLUSIONS:</p><p>Individual changes in TSH and thyroid hormones even within the normal reference range were an additional risk factor of incident type 2 diabetes.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 54255, member: 3"] Thyroid. 2016 Nov 3. [Epub ahead of print] [B]The association between changes in thyroid hormones and incident type 2 diabetes: A 7-year longitudinal study.[/B] Jun JE1, Jin SM2, Bae JC3, Jee JH4, Hur KY5, Lee MK6, Kim TH7, Kim SW8,9, Kim JH10. Abstract BACKGROUND: Thyroid hormones are important regulators of glucose homeostasis; however, the association between thyroid hormones within the reference range and type 2 diabetes remains unclear. The aim of this study was to clarify the incidence of type 2 diabetes according to the baseline levels and changes of thyroid stimulating hormone (TSH) and thyroid hormones (free thyroxine [FT4] and triiodothyronine [T3]) in euthyroid subjects. METHODS: Among the participants who consecutively underwent thyroid function tests between 2006 and 2012 through a yearly health check-up program, 6,235 euthyroid subjects (3,619 men and 2,616 women) without diabetes were enrolled in the study. The change in each hormone was calculated by subtracting the baseline value from the level at the end of follow-up or 1 year before the diagnosis of diabetes. RESULTS: During 25,692 person-years of follow-up, there were 229 new cases of type 2 diabetes. After full adjustment for potential confounders including HbA1c and fasting glucose in Cox proportional hazards models,[B] the individuals in the highest tertile of TSH change (2.5 to 4.2IU/mL) had a greater risk of incident type 2 diabetes (hazard ratio[/B] [HR][/HR] [B]=1.44, 95% confidence interval [CI]: 1.04 - 1.98, p for trend = 0.027) in comparison with individuals in the lowest tertile (-4.1 to -0.5 IU/mL). Simultaneously, the highest tertile of T3 change (16.3 to 104.7 ng/dL) and FT4 change (0.2 to 1.6 ng/dL) conferred protective effects against diabetes (HR = 0.60, 95% CI: 0.43-0.85, p for trend = 0.002 and HR = 0.34, 95% CI: 0.24 - 0.48, p for trend < 0.001, respectively) compared to those in the lowest tertile (-76.5 to -1.8 ng/dL and -0.6 to 0.0 ng/dL, respectively). These associations remained significant when each of the hormones was analyzed as a continuous variable. However, baseline levels or tertiles of TSH and thyroid hormones were not associated with the risk of diabetes.[/B] [HR][/HR] CONCLUSIONS: Individual changes in TSH and thyroid hormones even within the normal reference range were an additional risk factor of incident type 2 diabetes. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
The TSH Reference Range Wars: What's "Normal?", Who is Wrong, Who is Right...
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top