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Mental Health
The Case Against Antidepressants
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<blockquote data-quote="FunkOdyssey" data-source="post: 232724" data-attributes="member: 44064"><p>This paper argues you really can't call our current crop of antidepressant drugs antidepressants, because that isn't what they usually do. They more reliably cause particular side effects than relieve depression. Antiaphrodisiacs may be a more accurate term:</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820604/#" target="_blank">Scientifica (Cairo).</a> 2012; 2012: 965908.</p><p>Published online 2012 Jun 4. doi: <a href="https://doi.org/10.6064%2F2012%2F965908" target="_blank">10.6064/2012/965908</a></p><h3>Relabeling the Medications We Call Antidepressants</h3><p><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Antonuccio%20D%5BAuthor%5D" target="_blank">David Antonuccio</a> 1 , 2 ,* and <a href="https://pubmed.ncbi.nlm.nih.gov/?term=Healy%20D%5BAuthor%5D" target="_blank">David Healy</a> 3</p><h3>Abstract</h3><p>This paper raises the question about whether the data on the medications we call antidepressants justify the label of antidepressant. The authors argue that a true antidepressant should be clearly superior to placebo, should offer a risk/benefit balance that exceeds that of alternative treatments, should not increase suicidality, should not increase anxiety and agitation, should not interfere with sexual functioning, and should not increase depression chronicity. Unfortunately, these medications appear to fall short on all of these dimensions. Many of the “side effects” of these medications have larger effect sizes than the antidepressant effect size. To call these medications antidepressants may make sense from a marketing standpoint but may be misleading from a scientific perspective. Consumers deserve a label that more accurately reflects the data on the largest effects and helps them understand the range of effects from these medications. In other words, it may make just as much sense to call these medications antiaphrodisiacs as antidepressants because the negative effects on libido and sexual functioning are so common. It can be argued that a misleading label may interfere with our commitment to informed consent. Therefore, it may be time to stop calling these medications antidepressants.</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820604/[/URL]</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 232724, member: 44064"] This paper argues you really can't call our current crop of antidepressant drugs antidepressants, because that isn't what they usually do. They more reliably cause particular side effects than relieve depression. Antiaphrodisiacs may be a more accurate term: [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820604/#']Scientifica (Cairo).[/URL] 2012; 2012: 965908. Published online 2012 Jun 4. doi: [URL='https://doi.org/10.6064%2F2012%2F965908']10.6064/2012/965908[/URL] [HEADING=2]Relabeling the Medications We Call Antidepressants[/HEADING] [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Antonuccio%20D%5BAuthor%5D']David Antonuccio[/URL] 1 , 2 ,* and [URL='https://pubmed.ncbi.nlm.nih.gov/?term=Healy%20D%5BAuthor%5D']David Healy[/URL] 3 [HEADING=2]Abstract[/HEADING] This paper raises the question about whether the data on the medications we call antidepressants justify the label of antidepressant. The authors argue that a true antidepressant should be clearly superior to placebo, should offer a risk/benefit balance that exceeds that of alternative treatments, should not increase suicidality, should not increase anxiety and agitation, should not interfere with sexual functioning, and should not increase depression chronicity. Unfortunately, these medications appear to fall short on all of these dimensions. Many of the “side effects” of these medications have larger effect sizes than the antidepressant effect size. To call these medications antidepressants may make sense from a marketing standpoint but may be misleading from a scientific perspective. Consumers deserve a label that more accurately reflects the data on the largest effects and helps them understand the range of effects from these medications. In other words, it may make just as much sense to call these medications antiaphrodisiacs as antidepressants because the negative effects on libido and sexual functioning are so common. It can be argued that a misleading label may interfere with our commitment to informed consent. Therefore, it may be time to stop calling these medications antidepressants. [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820604/[/URL] [/QUOTE]
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Mental Health
The Case Against Antidepressants
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