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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Raising ferritin FAST (a how-to, not a question)
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<blockquote data-quote="Cataceous" data-source="post: 209643" data-attributes="member: 38109"><p>So going from a massive dose (200 mg/wk) down to a large dose (125 mg/wk) makes no difference? But that doesn't say anything about physiological dosing.</p><p></p><p>Free T is important, but there's no evidence that being above your own healthy natural set point is a good thing overall. About half the healthy population must have free T below the mean of that population. If members of this lower half later develop hypogonadism and go on TRT then they should initially target levels that are the best approximation of their own natural levels. They should not succumb to the more-is-better mentality. I'd further argue that if we don't know our optimal level <em>a priori</em> then it's safest to initially target the average of the healthy young population.</p><p></p><p>From a statistical and technical viewpoint the opposite is true. The underlying metabolic clearance rate tends to lessen as we get older. This <em>increases</em> testosterone levels at the same dose. I'm not arguing that you personally would do well at 40 mg TC/week, but your numbers do suggest that 75 mg would still put your free T in the healthy normal range. Furthermore, using 75 mg equivalent in an ester blend would allow daily peak free and total testosterone to be considerably higher than otherwise, possibly without the negative HCT consequences.</p><p></p><p>I'm sympathetic to the fact that you don't want to tamper with an otherwise successful protocol. But in my opinion trying to carve out exceptions for guys on TRT is wrong. What's our goal with TRT? Do we want to imitate healthy 30-year-olds or do we want to be old guys with excessive testosterone who must donate blood, take AIs, etc.?</p></blockquote><p></p>
[QUOTE="Cataceous, post: 209643, member: 38109"] So going from a massive dose (200 mg/wk) down to a large dose (125 mg/wk) makes no difference? But that doesn't say anything about physiological dosing. Free T is important, but there's no evidence that being above your own healthy natural set point is a good thing overall. About half the healthy population must have free T below the mean of that population. If members of this lower half later develop hypogonadism and go on TRT then they should initially target levels that are the best approximation of their own natural levels. They should not succumb to the more-is-better mentality. I'd further argue that if we don't know our optimal level [I]a priori[/I] then it's safest to initially target the average of the healthy young population. From a statistical and technical viewpoint the opposite is true. The underlying metabolic clearance rate tends to lessen as we get older. This [I]increases[/I] testosterone levels at the same dose. I'm not arguing that you personally would do well at 40 mg TC/week, but your numbers do suggest that 75 mg would still put your free T in the healthy normal range. Furthermore, using 75 mg equivalent in an ester blend would allow daily peak free and total testosterone to be considerably higher than otherwise, possibly without the negative HCT consequences. I'm sympathetic to the fact that you don't want to tamper with an otherwise successful protocol. But in my opinion trying to carve out exceptions for guys on TRT is wrong. What's our goal with TRT? Do we want to imitate healthy 30-year-olds or do we want to be old guys with excessive testosterone who must donate blood, take AIs, etc.? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Raising ferritin FAST (a how-to, not a question)
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