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Nettle Root Binds to SHBG
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<blockquote data-quote="Cataceous" data-source="post: 233232" data-attributes="member: 38109"><p>Newer thinking is that SHBG has minimal influence on free testosterone. Instead it is the testosterone production rate or dose rate that drives free testosterone at steady state. If nettle root does effectively reduce the amount of SHBG then one might expect reduced total testosterone, but little change in free testosterone after stabilization.</p><p></p><p>An acute effect seems possible. If the relevant nettle root lignans increase quickly in the blood then a short-lived increase in free testosterone might be expected. It's unclear if this would have any real-world significance. In the best case the lignans aren't metabolized very quickly, thus avoiding a subsequent lowering of free testosterone below baseline.</p><p></p><p>The Internet, a place where anyone can publish authoritative sounding rubbish:</p><p></p><p style="margin-left: 20px"><em>For most healthy individuals, High levels of estrogen and testosterone are damaging only after they have become bound to SHBG . Once estrogen or testosterone have become bound to SHBG, they begin the process of being converted into harmful estrogen metabolites, like estradiol. By keeping these sex hormones free, the rates of conversion to harmful metabolites are decreased.</em></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253158/" target="_blank">Peer-reviewed</a> statements are more useful:</p><p></p><p style="margin-left: 20px"><em>Lignans from root extract inhibit not only the binding of androgens to their transporter proteins SHBG (Sex Hormone Binding Globulin), but also their binding to the prostate’s membrane receptors, inhibiting their proliferative activity on prostate tissues (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253158/#bib83" target="_blank">Schöttner et al., 1997</a>; <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253158/#bib20" target="_blank">Chrubasik et al., 2007</a>; <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253158/#bib40" target="_blank">Hryb et al., 1995</a>). The root extract reduces estrogen synthesis and thus the conversion of androgens to estrogens via blocking aromatase (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253158/#bib31" target="_blank">Gansser and Spiteller, 1995</a>).</em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 233232, member: 38109"] Newer thinking is that SHBG has minimal influence on free testosterone. Instead it is the testosterone production rate or dose rate that drives free testosterone at steady state. If nettle root does effectively reduce the amount of SHBG then one might expect reduced total testosterone, but little change in free testosterone after stabilization. An acute effect seems possible. If the relevant nettle root lignans increase quickly in the blood then a short-lived increase in free testosterone might be expected. It's unclear if this would have any real-world significance. In the best case the lignans aren't metabolized very quickly, thus avoiding a subsequent lowering of free testosterone below baseline. The Internet, a place where anyone can publish authoritative sounding rubbish: [INDENT][I]For most healthy individuals, High levels of estrogen and testosterone are damaging only after they have become bound to SHBG . Once estrogen or testosterone have become bound to SHBG, they begin the process of being converted into harmful estrogen metabolites, like estradiol. By keeping these sex hormones free, the rates of conversion to harmful metabolites are decreased.[/I][/INDENT] [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253158/']Peer-reviewed[/URL] statements are more useful: [INDENT][I]Lignans from root extract inhibit not only the binding of androgens to their transporter proteins SHBG (Sex Hormone Binding Globulin), but also their binding to the prostate’s membrane receptors, inhibiting their proliferative activity on prostate tissues ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253158/#bib83']Schöttner et al., 1997[/URL]; [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253158/#bib20']Chrubasik et al., 2007[/URL]; [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253158/#bib40']Hryb et al., 1995[/URL]). The root extract reduces estrogen synthesis and thus the conversion of androgens to estrogens via blocking aromatase ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253158/#bib31']Gansser and Spiteller, 1995[/URL]).[/I][/INDENT] [/QUOTE]
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Nettle Root Binds to SHBG
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