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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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<blockquote data-quote="Cataceous" data-source="post: 212526" data-attributes="member: 38109"><p>In actuality, the component of insulin resistance associated with receptors simply refers to down-regulation[<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170977/" target="_blank">R</a>], i.e. decreasing numbers of receptors. So effectively you are claiming that nandrolone up-regulates estrogen receptors. But progestins do the opposite. So I think definitive references are needed to support this claim.</p><p></p><p>Then surely you can link to at least one study. I'm not saying it's wrong at this point, but I have to wonder how aromatization can be increased with a steroid that's androgenic and progestogenic. This would be relative to hormones with purer forms of either property, such as testosterone or progesterone. In fact pure progesterone has some aromatase-inhibiting ability.</p><p></p><p>This was being argued in another thread. Nandrolone has a relative binding affinity for the progesterone receptor that is perhaps 20% of progesterone's affinity. However, so far nobody has offered definitive evidence that nandrolone's effects are weaker once it is bound. There is one parameter of activity in one animal study that is lower, but it will take more than that to decide the issue.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 212526, member: 38109"] In actuality, the component of insulin resistance associated with receptors simply refers to down-regulation[[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170977/']R[/URL]], i.e. decreasing numbers of receptors. So effectively you are claiming that nandrolone up-regulates estrogen receptors. But progestins do the opposite. So I think definitive references are needed to support this claim. Then surely you can link to at least one study. I'm not saying it's wrong at this point, but I have to wonder how aromatization can be increased with a steroid that's androgenic and progestogenic. This would be relative to hormones with purer forms of either property, such as testosterone or progesterone. In fact pure progesterone has some aromatase-inhibiting ability. This was being argued in another thread. Nandrolone has a relative binding affinity for the progesterone receptor that is perhaps 20% of progesterone's affinity. However, so far nobody has offered definitive evidence that nandrolone's effects are weaker once it is bound. There is one parameter of activity in one animal study that is lower, but it will take more than that to decide the issue. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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