ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My Ongoing TRT Mystery
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Simbarn" data-source="post: 240223" data-attributes="member: 44021"><p>This is interesting, do you have any links to this research with female to male trans people?</p><p>I have arrived at the supposition given my research on the topic that TRT can elevate the activity of our sympathetic nervous system in many men. In effect it may cause an imbalance in the sympathetic and parasympathetic nervous systems, (sympathetic NS dominance) which can lead to to anxiety and erectile/sexual difficulties. The penis has its own delicate balance of these two systems, which can be quite susceptible to changes in sympathetic activity in the penis itself. It may also cause issues with the RAS system up-regulating angiotensin II, which will also negatively influence erectile function.</p><p>It could be that the way in which exogenous testosterone is delivered into the body, which differs from the very intricate natural diurnal natural production, causes these issues. It may also be the loss of our gonadotropins (plus other upstream hormones), specifically LH, that contribute to this exacerbation of sympathetic function.</p><p></p><p>It is very interesting to me that you have found that your sexual function has been markedly improved whilst on a SSRI and testosterone replacement combined. Perhaps this is modulating sympathetic activity to the point whereby erectile function can function more normally again. Your experience with Benzos also mirrors mine, however, these drugs cannot be used long term due to drug tolerance as we all know. </p><p></p><p>I have spent years researching erectile function specifically, the balance between the sympathetic and parasympathetic activity in the erectile tissues is critical to good erectile function. The mechanisms that keep the penis in a flaccid state 95% of our waking hours are very powerful and have backup systems to ensure the penis stays that way in order to protect it in times of danger. Excess T, even possibly just a small amount may cause significant sexual issues, not to mention psychological issues, either directly or indirectly via the above pathways.</p><p></p><p>Some men are more sensitive to the upregulation of Norepinephrine in the penis than others. Research is also suggesting that this upregulation may occur due to ageing and may be evident even in middle aged men.</p><p></p><p>Th reason why PDE5i can significantly help men with the above NE (and Rho-kinase pathway) imbalance in the penis, is because they give the pro-erectile pathways (NO Pathway) more power, thus helping to overcome the excessive inhibitory mechanism in these tissues, restoring some balance, so to speak.</p></blockquote><p></p>
[QUOTE="Simbarn, post: 240223, member: 44021"] This is interesting, do you have any links to this research with female to male trans people? I have arrived at the supposition given my research on the topic that TRT can elevate the activity of our sympathetic nervous system in many men. In effect it may cause an imbalance in the sympathetic and parasympathetic nervous systems, (sympathetic NS dominance) which can lead to to anxiety and erectile/sexual difficulties. The penis has its own delicate balance of these two systems, which can be quite susceptible to changes in sympathetic activity in the penis itself. It may also cause issues with the RAS system up-regulating angiotensin II, which will also negatively influence erectile function. It could be that the way in which exogenous testosterone is delivered into the body, which differs from the very intricate natural diurnal natural production, causes these issues. It may also be the loss of our gonadotropins (plus other upstream hormones), specifically LH, that contribute to this exacerbation of sympathetic function. It is very interesting to me that you have found that your sexual function has been markedly improved whilst on a SSRI and testosterone replacement combined. Perhaps this is modulating sympathetic activity to the point whereby erectile function can function more normally again. Your experience with Benzos also mirrors mine, however, these drugs cannot be used long term due to drug tolerance as we all know. I have spent years researching erectile function specifically, the balance between the sympathetic and parasympathetic activity in the erectile tissues is critical to good erectile function. The mechanisms that keep the penis in a flaccid state 95% of our waking hours are very powerful and have backup systems to ensure the penis stays that way in order to protect it in times of danger. Excess T, even possibly just a small amount may cause significant sexual issues, not to mention psychological issues, either directly or indirectly via the above pathways. Some men are more sensitive to the upregulation of Norepinephrine in the penis than others. Research is also suggesting that this upregulation may occur due to ageing and may be evident even in middle aged men. Th reason why PDE5i can significantly help men with the above NE (and Rho-kinase pathway) imbalance in the penis, is because they give the pro-erectile pathways (NO Pathway) more power, thus helping to overcome the excessive inhibitory mechanism in these tissues, restoring some balance, so to speak. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My Ongoing TRT Mystery
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top