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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Microdosing Enanthate
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<blockquote data-quote="Cataceous" data-source="post: 215232" data-attributes="member: 38109"><p>I agree that HPTA shutdown is pretty complete in most guys even with low TRT doses. It appears that the duration of exposure to exogenous testosterone in addition to the amount are what drive it. The testosterone nasal gels put serum testosterone up to high-normal levels, but the higher levels last only for an hour or so. This leads to only minor effects on the HPTA.</p><p></p><p>You may have seen my compilation of links where guys on here talk about feeling better on lower doses. Since it's not about HPTA shutdown it could be about balance. One of the balances we talk about is the ratio of estradiol to testosterone. At least in theory this doesn't change much with TRT dose ranges that aren't extreme. However, androgens and estrogens interact with countless other bodily processes, sometimes independently of one another. In these instances the absolute levels are important. One obvious example is when excessive testosterone raises hematocrit. Now imagine if there are dozens of other processes that are thrown off in more subtle ways when testosterone and/or estradiol are too high for the individual—which can occur even if the hormones are within their reference ranges. This is why I promote a slow treatment progression from more natural to less natural: Start with nasal gel to get higher testosterone without HPTA suppression. If absolutely necessary then progress to conventional TRT at lower doses. If necessary then slowly increase the doses.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 215232, member: 38109"] I agree that HPTA shutdown is pretty complete in most guys even with low TRT doses. It appears that the duration of exposure to exogenous testosterone in addition to the amount are what drive it. The testosterone nasal gels put serum testosterone up to high-normal levels, but the higher levels last only for an hour or so. This leads to only minor effects on the HPTA. You may have seen my compilation of links where guys on here talk about feeling better on lower doses. Since it's not about HPTA shutdown it could be about balance. One of the balances we talk about is the ratio of estradiol to testosterone. At least in theory this doesn't change much with TRT dose ranges that aren't extreme. However, androgens and estrogens interact with countless other bodily processes, sometimes independently of one another. In these instances the absolute levels are important. One obvious example is when excessive testosterone raises hematocrit. Now imagine if there are dozens of other processes that are thrown off in more subtle ways when testosterone and/or estradiol are too high for the individual—which can occur even if the hormones are within their reference ranges. This is why I promote a slow treatment progression from more natural to less natural: Start with nasal gel to get higher testosterone without HPTA suppression. If absolutely necessary then progress to conventional TRT at lower doses. If necessary then slowly increase the doses. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Microdosing Enanthate
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