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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG = lower dosed, more frequent injections. Why?
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<blockquote data-quote="Cataceous" data-source="post: 211837" data-attributes="member: 38109"><p>There are some good reasons to believe that the dose of testosterone is directly, i.e. proportionally, driving free testosterone, not total. I often refer to a thought experiment involving twins on TRT, identical except for SHBG. When the dose rate of testosterone is identical then the twins have the same free testosterone. However, the twin with lower SHBG has lower total testosterone than the one with higher SHBG.</p><p></p><p>It's not definitively known why low SHBG is problematic. Possible reasons include the relatively higher free estradiol seen at a given level of free testosterone. It's speculated that a lack of SHBG interferes with intracellular delivery of testosterone. In addition, some SHBG-bound testosterone is delivered directly to cell receptors.</p><p></p><p>It's possible that smaller and more frequent testosterone injections help to limit the ratio of free estradiol to free testosterone. Larger, less frequent doses could allow excursions into non-physiological ratios, leading to side effects.</p><p></p><p>Edit: The premise of free estradiol increasing relative to free testosterone at low SHBG is based on an assumption of total estradiol being driven directly by free testosterone. But it seems more likely that free estradiol follows free testosterone, making total estradiol the dependent variable. In other words, neither free estradiol nor free testosterone changes much when SHBG is reduced in isolation. It's still plausible that lower SHBG leads to reduced androgenic activity relative to estrogenic activity—without a dependence on the free hormone levels.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 211837, member: 38109"] There are some good reasons to believe that the dose of testosterone is directly, i.e. proportionally, driving free testosterone, not total. I often refer to a thought experiment involving twins on TRT, identical except for SHBG. When the dose rate of testosterone is identical then the twins have the same free testosterone. However, the twin with lower SHBG has lower total testosterone than the one with higher SHBG. It's not definitively known why low SHBG is problematic. Possible reasons include the relatively higher free estradiol seen at a given level of free testosterone. It's speculated that a lack of SHBG interferes with intracellular delivery of testosterone. In addition, some SHBG-bound testosterone is delivered directly to cell receptors. It's possible that smaller and more frequent testosterone injections help to limit the ratio of free estradiol to free testosterone. Larger, less frequent doses could allow excursions into non-physiological ratios, leading to side effects. Edit: The premise of free estradiol increasing relative to free testosterone at low SHBG is based on an assumption of total estradiol being driven directly by free testosterone. But it seems more likely that free estradiol follows free testosterone, making total estradiol the dependent variable. In other words, neither free estradiol nor free testosterone changes much when SHBG is reduced in isolation. It's still plausible that lower SHBG leads to reduced androgenic activity relative to estrogenic activity—without a dependence on the free hormone levels. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Low SHBG = lower dosed, more frequent injections. Why?
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