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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Increased SHBG and not testosterone or estradiol is associated with bone loss and fractures
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<blockquote data-quote="Nelson Vergel" data-source="post: 44981" data-attributes="member: 3"><p>This makes sense since higher SHBG would result in lower free estradiol which is probably the main factor in bone density. They do not mention the relation between free testosterone and bone.<strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Progressive Temporal Change in Serum SHBG, but not in Serum Testosterone or Estradiol, Is Associated with Bone Loss and Incident Fractures in Older Men: The Concord Health and Ageing in Men Project</strong></p><p></p><p><strong>ABSTRACT</strong></p><p></p><p></p><p>This study aimed to examine progressive temporal relationships between changes in major reproductive hormones across three waves of a cohort study of older men and (a) changes in bone mineral density (BMD) and (b) incident fractures (any, hip or non-vertebral) over an average of 6-years follow-up. The CHAMP cohort of men aged 70 years and older were assessed at baseline (2005-07, n&#8201;=&#8201;1705), 2-year (n&#8201;=&#8201;1367) and 5-year follow-up (n&#8201;=&#8201;958). Serum testosterone (T), dihydrotestosterone (DHT), estradiol (E2), and estrone (E1) (by liquid chromatography-tandem mass spectrometry (LC-MS/MS)), and of SHBG, LH and FSH (by immunoassay) were measured at all time-points, while free testosterone (cFT) was calculated using a well validated formula. Hip BMD was measured by dual X-ray absorptiometry (DXA) at all three time-points, and fracture data were verified radiographically. Statistical modeling was done using general estimating equations (GEE). For total hip BMD, univariable analyses revealed inverse associations with temporal changes in serum SHBG, FSH and LH and positive associations for serum E1 and cFT across the three time-points. In models adjusted for multiple covariables, serum SHBG (&#946;&#8201;=&#8201;-0.029), FSH (&#946;&#8201;=&#8201;-0.065), LH (&#946;&#8201;=&#8201;-0.049), E1 (&#946;&#8201;=&#8201;0.019) and cFT (&#946;&#8201;=&#8201;0.033) remained significantly associated with hip BMD. However for femoral neck BMD, only FSH (&#946;&#8201;=&#8201;-0.048) and LH (&#946;&#8201;=&#8201;-0.036) remained associated in multivariable-adjusted models. Temporal change in serum SHBG, but not T, E2 or other hormonal variables, was significantly associated with any, non-vertebral or hip fracture incidence in univariable analyses. In multivariable-adjusted models, temporal increase in serum SHBG over time remained associated with any (&#946;&#8201;=&#8201;0.060) and hip fracture (&#946;&#8201;=&#8201;0.041) but not non-vertebral fracture incidence. T<strong>hese data indicate that a progressive increase in circulating SHBG over time predicts bone loss and fracture risk in older men. Further studies are warranted to further characterize changes in circulating SHBG as a mechanism and/or biomarker of bone health during male ageing.</strong></p><p><strong></strong></p><p> <strong></strong><a href="http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2904/abstract" target="_blank">http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2904/abstract</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 44981, member: 3"] This makes sense since higher SHBG would result in lower free estradiol which is probably the main factor in bone density. They do not mention the relation between free testosterone and bone.[B] Progressive Temporal Change in Serum SHBG, but not in Serum Testosterone or Estradiol, Is Associated with Bone Loss and Incident Fractures in Older Men: The Concord Health and Ageing in Men Project[/B] [B]ABSTRACT[/B] This study aimed to examine progressive temporal relationships between changes in major reproductive hormones across three waves of a cohort study of older men and (a) changes in bone mineral density (BMD) and (b) incident fractures (any, hip or non-vertebral) over an average of 6-years follow-up. The CHAMP cohort of men aged 70 years and older were assessed at baseline (2005-07, n = 1705), 2-year (n = 1367) and 5-year follow-up (n = 958). Serum testosterone (T), dihydrotestosterone (DHT), estradiol (E2), and estrone (E1) (by liquid chromatography-tandem mass spectrometry (LC-MS/MS)), and of SHBG, LH and FSH (by immunoassay) were measured at all time-points, while free testosterone (cFT) was calculated using a well validated formula. Hip BMD was measured by dual X-ray absorptiometry (DXA) at all three time-points, and fracture data were verified radiographically. Statistical modeling was done using general estimating equations (GEE). For total hip BMD, univariable analyses revealed inverse associations with temporal changes in serum SHBG, FSH and LH and positive associations for serum E1 and cFT across the three time-points. In models adjusted for multiple covariables, serum SHBG (β = -0.029), FSH (β = -0.065), LH (β = -0.049), E1 (β = 0.019) and cFT (β = 0.033) remained significantly associated with hip BMD. However for femoral neck BMD, only FSH (β = -0.048) and LH (β = -0.036) remained associated in multivariable-adjusted models. Temporal change in serum SHBG, but not T, E2 or other hormonal variables, was significantly associated with any, non-vertebral or hip fracture incidence in univariable analyses. In multivariable-adjusted models, temporal increase in serum SHBG over time remained associated with any (β = 0.060) and hip fracture (β = 0.041) but not non-vertebral fracture incidence. T[B]hese data indicate that a progressive increase in circulating SHBG over time predicts bone loss and fracture risk in older men. Further studies are warranted to further characterize changes in circulating SHBG as a mechanism and/or biomarker of bone health during male ageing. [/B][URL]http://onlinelibrary.wiley.com/doi/10.1002/jbmr.2904/abstract[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Increased SHBG and not testosterone or estradiol is associated with bone loss and fractures
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