I need help managing side effects of TRT

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Jekyll900sl

New Member
Hi forum members,
I have combed through many threads and cannot find the help I feel I need. So I figured, I'd just ask for the help.

Long story short; in the spring of 2016, my Testosterone drop by about half. I suffered from overtraining syndrome (OTS) from what I researched. My HPA axis was all messed up and I felt awful. I stopped all exercise and was very depressed and slept 10hrs plus per day. I went to many specialist to find out how I could stop the suffering I was experiencing. The only lab that changed over this time was my Testosterone. So I thought that was the answer. I needed to start hormone therapy. I put what little energy I had into finding a doctor that would be willing to see if this was what I needed to feel better. It took a year to find a clinic that would start me on TRT. They just started me on a cookie cutter program and had me taking way too much testosterone per week. I gained at least 20lbs in the first few months. I think it took 3 months before I felt like I could exercise and not feel awful afterwards. So I guess it worked, but it did not help with the other issues I was having; ED and no sex drive. (This wasn't a slow progression, so not age related. This happened in 3 months)

After my PCP agreed to Rx testosterone to me, I started to play with the dosage and I dropped the AI completely from my protocol. I thought it was keeping me from gaining more water weight, but it made me feel super depressed.

Fast forward to now. I cannot lose weight and I am still having ED and libido issues. I have been doing the 8/16 fast and haven't lost any weight. I think I am eating around 2000-2500 Kcal a day!! My weight does go up and down throughout the week but always returns to 183lbs. Is it the dose or timing of my shot?? I am using boner pills and they work mostly, but sex does not feel the way it used to. I don't have much desire and my unit feels numb sometimes..

Here is my current protocol:
Testosterone cypionate in GSO-->0.3mL (60mg) of 5mL/200mg dose twice a week (incase my math is incorrect)
HcG--> 60 units twice a week. 12,000 IU vial.
No AI, when I have used it, it caused depression.

*I am going to try a compounded cream and have an Rx in at Empower. I think my body would like to get back to the circadian rhythm it had. I also read it might help with libido because of DHT.

I am 44 and weigh 183lbs. I was an endurance athlete (bike, run, nordic ski) and was able to train 20 hours per week. That included weight training. I also used to be 165lbs. I am back to doing most things I used to do but not to the level I used to. I feel good when I lift weights but find it boring and hard to stick with. I really like Crossfit but I can never practice the lifts I want to master because of limited time outside of classes. I have many excuses because I don't have the energy I used to. I will be going to grad school shortly and will have to rely on Crossfit classes to stay fit.

Lastly, does anyone know of a doctor as knowledgeable as Dr. Rand McClain at Regenerative Sports and Medicine in SoCal. I cannot afford $800 per session or I would be consulting him.

I will attach the spreadsheet in which I compiled all labs I have had.

Thanks in advance for the help. I will not be offended, I wear big boy pants, so let the comments fly (talking to you Madman) I will answer questions about anything I missed. I tried to give as much information as I could.
 

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Systemlord

Member
*I am going to try a compounded cream and have an Rx in at Empower. I think my body would like to get back to the circadian rhythm it had. I also read it might help with libido because of DHT.
If the cream doesn't work out for you I would then recommend Jatenzo, a relatively new oral capsule dosed twice daily with food/fats.

Jatenzo is something you want your insurance to pay for as its quite costly. It's a bit of a middle ground, it produces higher Free T versus creams, higher DHT versus injections.

The difference in levels in a 12 hour period are on average 980 at peak (2 hours) and 287 at 12 hours. It starts all over in the evening.

The recommended starting dosage for Jatenzo is 237mg twice daily. Most men in the clinical trial need 237mg or more.

A steady state on Jatenzo is reach in 7 days at which levels are measured and dosing adjustments are made.

Jatenzo is also less suppressive compared to injections and cream allowing LH and FSH to remain in the low normal range.
 
Last edited:

Jekyll900sl

New Member
If the cream doesn't work out for you I would then recommend Jatenzo, a relatively new oral capsule dosed twice daily with food/fats.

Jatenzo is something you want your insurance to pay for as its quite costly. It's a bit of a middle ground, it produces higher Free T versus creams, higher DHT versus injections.

The difference in levels in a 12 hour period are on average 980 at peak (2 hours) and 287 at 12 hours. It starts all over in the evening.

The recommended starting dosage for Jatenzo is 237mg twice daily. Most men in the clinical trial need 237mg or more.

A steady state on Jatenzo is reach in 7 days at which levels are measured and dosing adjustments are made.

Jatenzo is also less suppressive compared to injections and cream allowing LH and FSH to remain in the low normal range.
I looked into trying Jatenzo. My insurance would probably put up a fight to cover it. Injections and cream are by far more affordable, I will be headed to grad school soon so healthcare coverage might get more difficult for a year or two. Thanks for your input.
 

Systemlord

Member
I looked into trying Jatenzo. My insurance would probably put up a fight to cover it.
My endo gave me a medical exception because all other treatment options failed over a 4-year period and I was at high risk for diabetes complications. All previous type diabetes medications cause potassium deficiency and I'm allergic to insulin.
 
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