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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
HCG Efficacy: Should We Measure 17-OH-progesterone to Titrate HCG Dose?
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<blockquote data-quote="Formula364" data-source="post: 52730" data-attributes="member: 13948"><p>So, the StAR expression is stimulated by LH (hCG mimics), which starts the p450scc enzyme to produce Pregnenolone from cholesterol. Then Pregnenolone converts to <u>Progesterone</u> (3B-HSD via StAR) or to <u>17OH-Pregnenolone</u> (17,20 lyase via StAR). These two can convert to 17OH-Progesterone (by same enzyme conversions) - which you are now going to start measuring.</p><p>Does anyone know the rates of these enzyme conversions? Is one weaker or stronger than the other?</p><p>Would supplementing with a small amount of Pregnenolone while on TRT + hCG enhance the conversion process? My thinking here is: if less hCG is needed for the P450scc to convert to Pregnenolone, there would be more hCG available for the other downstream conversions?</p></blockquote><p></p>
[QUOTE="Formula364, post: 52730, member: 13948"] So, the StAR expression is stimulated by LH (hCG mimics), which starts the p450scc enzyme to produce Pregnenolone from cholesterol. Then Pregnenolone converts to [U]Progesterone[/U] (3B-HSD via StAR) or to [U]17OH-Pregnenolone[/U] (17,20 lyase via StAR). These two can convert to 17OH-Progesterone (by same enzyme conversions) - which you are now going to start measuring. Does anyone know the rates of these enzyme conversions? Is one weaker or stronger than the other? Would supplementing with a small amount of Pregnenolone while on TRT + hCG enhance the conversion process? My thinking here is: if less hCG is needed for the P450scc to convert to Pregnenolone, there would be more hCG available for the other downstream conversions? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
HCG Efficacy: Should We Measure 17-OH-progesterone to Titrate HCG Dose?
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