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Different Types of Iron Deficiency
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<blockquote data-quote="madman" data-source="post: 208498" data-attributes="member: 13851"><p><strong>Figure 2: <u>Absolute and functional iron deficiency</u> In <u>absolute iron deficiency</u>, total body iron concentrations are reduced due to uncompensated negative iron balance. Patients with absolute iron deficiency have low tissue iron stores, low bone marrow iron stores, and low plasma iron (transferrin saturation), and in the absence of other signals, hepcidin is suppressed homoeostatically upregulating iron absorption. Anaemia of inflammation is common in patients with conditions including acute and chronic infection, autoimmune conditions, cancer, recent surgery, and heart failure. The predominant mechanism of anaemia of inflammation is functional iron deficiency, in which inflammation-mediated increases in hepcidin prevent cellular iron export (especially from macrophages) to the plasma, resulting in reduced transferrin saturation, iron-deficient erythropoiesis, and anaemia, even with sufficient body iron stores. <u>Functional iron deficiency</u> is the predominant mechanism of anaemia of inflammation, but other causes (eg, direct bone marrow suppression, reduced erythropoietin production and marrow responsiveness, and reduced red blood cell survival) can also contribute. <u>Functional and absolute iron deficiency can coexist</u>, and functional iron deficiency might promote absolute iron deficiency through sustained impairment of iron uptake. <u>Therapy for absolute iron deficiency</u> focuses on improving iron stores, ameliorating blood losses, and optimising iron absorption. <u>Therapy for functional iron deficiency</u> focuses on controlling the underlying conditions. Parenteral iron therapy can be used if the patient is symptomatically anaemic.</strong></p><p><strong>[ATTACH=full]16648[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 208498, member: 13851"] [B]Figure 2: [U]Absolute and functional iron deficiency[/U] In [U]absolute iron deficiency[/U], total body iron concentrations are reduced due to uncompensated negative iron balance. Patients with absolute iron deficiency have low tissue iron stores, low bone marrow iron stores, and low plasma iron (transferrin saturation), and in the absence of other signals, hepcidin is suppressed homoeostatically upregulating iron absorption. Anaemia of inflammation is common in patients with conditions including acute and chronic infection, autoimmune conditions, cancer, recent surgery, and heart failure. The predominant mechanism of anaemia of inflammation is functional iron deficiency, in which inflammation-mediated increases in hepcidin prevent cellular iron export (especially from macrophages) to the plasma, resulting in reduced transferrin saturation, iron-deficient erythropoiesis, and anaemia, even with sufficient body iron stores. [U]Functional iron deficiency[/U] is the predominant mechanism of anaemia of inflammation, but other causes (eg, direct bone marrow suppression, reduced erythropoietin production and marrow responsiveness, and reduced red blood cell survival) can also contribute. [U]Functional and absolute iron deficiency can coexist[/U], and functional iron deficiency might promote absolute iron deficiency through sustained impairment of iron uptake. [U]Therapy for absolute iron deficiency[/U] focuses on improving iron stores, ameliorating blood losses, and optimising iron absorption. [U]Therapy for functional iron deficiency[/U] focuses on controlling the underlying conditions. Parenteral iron therapy can be used if the patient is symptomatically anaemic. [ATTACH type="full"]16648[/ATTACH][/B] [/QUOTE]
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Different Types of Iron Deficiency
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