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Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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<blockquote data-quote="Marco N Cognito" data-source="post: 5673" data-attributes="member: 13"><p>We have not been able to determine an exact cause of the clots in either case, although I do show +/+ (homozygous) for the MTHFR C667T gene mutation, but homocysteine was normal (7.0), and am +/- (heterozygous) for PAI-1 gene mutation. </p><p>All of the other genetic tests known to cause thrombosis resulted in negatives (Lupus Anticogulant, Anticardiolipin antibodies, Antiphospholipid antibodies, Leukemia, Lymphoma, Factor XI, APOE E mutation, protein C, S, prothrombin 20210A, PNH, Factor V Leiden). I was also not on any testosterone replacement during the time of the clots nor when these labs were drawn:</p><p></p><p>Following are my ultrasound reports from my two separate thromboses which occurred in 2012, one in each leg (they both cleared within a couple weeks with no further incidence or symptoms; I was on warfarin for the first one for 4 mos. and then stopped). </p><p><strong></strong></p><p><strong>Non-Occlusive DVT:</strong></p><p><a href="https://app.box.com/s/icyio8g4qqs1a0t513pn" target="_blank">https://app.box.com/s/icyio8g4qqs1a0t513pn</a></p><p><strong>Occlusive superficial VT:</strong></p><p><a href="https://app.box.com/s/pwcbckxc9v5x89olzz4m" target="_blank">https://app.box.com/s/pwcbckxc9v5x89olzz4m</a> </p><p></p><p>The factors that are showing increased elevation since the two 2012 episodes are:</p><p><strong>d-dimer: 1.2 in Nov. '12; 0.80 in Sept. '13; 0.50 in Nov. '13 - ref range: 0.0 &#8722; 0.4ug FEU/mL</strong> </p><p><strong>Factor XII: 197 in July '13; 180 in Sep. '13 - ref range: 50 &#8722; 150%</strong> </p><p><strong>Factor V: 141 in Sept. '13; 113 in Nov. '13 - ref range: 60 &#8722; 140%</strong> </p><p><strong>Factor VIII: 171 in Nov. '12; 191 in Sept. '13; 122 in Nov '13 - ref range: 50 &#8722; 150%</strong> </p><p><strong>Factor XII: 197 in July '13; 180 in Sept. '13 - ref range: 50 &#8722; 150%</strong> </p><p><strong>von Willebrand Factor: 206 in Sept. '13; 169 in Nov. '13 - ref range: 50 &#8722; 150%</strong> </p><p></p><p>When I asked my hematologist's opinion on these out of range levels, his answer was that there are "not clinically significant." His answer is based on his opinion that it's unnecessary to anticoagulate in the absence of a DVT. </p><p><strong></strong></p><p><strong>My HCT (43.30) and HGB (13.70) are normal and I have the APO E 3/3 genotype.</strong> </p><p><strong>My Lp(a) level recently increased also: 124 on Nov. '13 (I have read that Lp(a) can be thrombogenic itself)</strong> </p><p><strong>My estradiol is currently very low: 5.0 on Nov. '13 (I could actually use some testosterone!)</strong> </p><p><strong>During the period in which my thromboses occurred my estradiol was the following:</strong> </p><p><strong>March, '12: <11.80</strong> </p><p><strong>Nov. '12: 10.0</strong> </p><p></p><p>Dr. Glueck's advice was the following: </p><p>"<em>Current practice suggests that any one with two thrombotic events, irrespective of etiology, should be anticoagulated for life. Of the clotting tests which look significant to me, there are two Factor VIII levels which would be high by our lab standards, and the von Willebrand's factor, which is just another way of measuring Factor VIII was also high. There is also a controversy in the literature whether MTHFR C677T homozygosity with normal homocysteine levels might be thrombophilic."</em></p><p><em></em></p><p>He further suggested Xarelto would be more efficient in preventing clots than the older anticoagulants.</p></blockquote><p></p>
[QUOTE="Marco N Cognito, post: 5673, member: 13"] We have not been able to determine an exact cause of the clots in either case, although I do show +/+ (homozygous) for the MTHFR C667T gene mutation, but homocysteine was normal (7.0), and am +/- (heterozygous) for PAI-1 gene mutation. All of the other genetic tests known to cause thrombosis resulted in negatives (Lupus Anticogulant, Anticardiolipin antibodies, Antiphospholipid antibodies, Leukemia, Lymphoma, Factor XI, APOE E mutation, protein C, S, prothrombin 20210A, PNH, Factor V Leiden). I was also not on any testosterone replacement during the time of the clots nor when these labs were drawn: Following are my ultrasound reports from my two separate thromboses which occurred in 2012, one in each leg (they both cleared within a couple weeks with no further incidence or symptoms; I was on warfarin for the first one for 4 mos. and then stopped). [B] Non-Occlusive DVT:[/B] [URL]https://app.box.com/s/icyio8g4qqs1a0t513pn[/URL] [B]Occlusive superficial VT:[/B] [URL]https://app.box.com/s/pwcbckxc9v5x89olzz4m[/URL] The factors that are showing increased elevation since the two 2012 episodes are: [B]d-dimer: 1.2 in Nov. '12; 0.80 in Sept. '13; 0.50 in Nov. '13 - ref range: 0.0 − 0.4ug FEU/mL[/B] [B]Factor XII: 197 in July '13; 180 in Sep. '13 - ref range: 50 − 150%[/B] [B]Factor V: 141 in Sept. '13; 113 in Nov. '13 - ref range: 60 − 140%[/B] [B]Factor VIII: 171 in Nov. '12; 191 in Sept. '13; 122 in Nov '13 - ref range: 50 − 150%[/B] [B]Factor XII: 197 in July '13; 180 in Sept. '13 - ref range: 50 − 150%[/B] [B]von Willebrand Factor: 206 in Sept. '13; 169 in Nov. '13 - ref range: 50 − 150%[/B] When I asked my hematologist's opinion on these out of range levels, his answer was that there are "not clinically significant." His answer is based on his opinion that it's unnecessary to anticoagulate in the absence of a DVT. [B] My HCT (43.30) and HGB (13.70) are normal and I have the APO E 3/3 genotype.[/B] [B]My Lp(a) level recently increased also: 124 on Nov. '13 (I have read that Lp(a) can be thrombogenic itself)[/B] [B]My estradiol is currently very low: 5.0 on Nov. '13 (I could actually use some testosterone!)[/B] [B]During the period in which my thromboses occurred my estradiol was the following:[/B] [B]March, '12: <11.80[/B] [B]Nov. '12: 10.0[/B] Dr. Glueck's advice was the following: "[I]Current practice suggests that any one with two thrombotic events, irrespective of etiology, should be anticoagulated for life. Of the clotting tests which look significant to me, there are two Factor VIII levels which would be high by our lab standards, and the von Willebrand's factor, which is just another way of measuring Factor VIII was also high. There is also a controversy in the literature whether MTHFR C677T homozygosity with normal homocysteine levels might be thrombophilic." [/I] He further suggested Xarelto would be more efficient in preventing clots than the older anticoagulants. [/QUOTE]
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Can Testosterone Induce Blood Clots and Thrombosis? Interview with Dr Charles Glueck
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