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General Health & Fitness
Nutrition and Supplements
Apigenin can make you a STAR! By Jerry Brainum
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<blockquote data-quote="Dr. John Crisler" data-source="post: 40453" data-attributes="member: 91"><p>I would offer an edit to Jerry's otherwise excellent article. </p><p></p><p>IGFBP-3, which is both primary carrier of IGF-1, and an important part of the p53 apoptosis (cancer cell seek-and-destroy) mechanism, does not "render IGF-1 harmless." Rather, it is a true carrier protein, and so extends the life of IGF-1. It is unlike SHBG, which powerfully binds sex hormones and (mostly) neutralizes them (there are issues with the previous, but more than we can get into here).</p><p></p><p>Since elevating IGFBP-3, which Apigenin does, increases IGF-1, it's more the counter balance of its effects on the p53 mechanism which lowers cancer risk. Quercetin does the same thing, in the same way.</p></blockquote><p></p>
[QUOTE="Dr. John Crisler, post: 40453, member: 91"] I would offer an edit to Jerry's otherwise excellent article. IGFBP-3, which is both primary carrier of IGF-1, and an important part of the p53 apoptosis (cancer cell seek-and-destroy) mechanism, does not "render IGF-1 harmless." Rather, it is a true carrier protein, and so extends the life of IGF-1. It is unlike SHBG, which powerfully binds sex hormones and (mostly) neutralizes them (there are issues with the previous, but more than we can get into here). Since elevating IGFBP-3, which Apigenin does, increases IGF-1, it's more the counter balance of its effects on the p53 mechanism which lowers cancer risk. Quercetin does the same thing, in the same way. [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
Apigenin can make you a STAR! By Jerry Brainum
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