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43 Year-old Male's TRT Journey
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<blockquote data-quote="madman" data-source="post: 209770" data-attributes="member: 13851"><p><em><strong>Thanks for the quick and great feedback, madman! Considering I'll be having to self-inject for the rest of my life, which will hopefully be many decades longer, I'd prefer to minimize frequency, balancing this with the parallel goal of keeping levels above 500ng/dl at trough and within 1200ng/dl at peak. With this, I'm hoping to avoid frequency of more often than every 5 days; perhaps 120mg/5 days.</strong></em></p><p></p><p>Need to get out of the mindset of getting caught up on TT.</p><p></p><p>FT is what truly matters as it is the unbound active fraction of T responsible for the positive effects.</p><p></p><p>Some may feel great overall with high-end trough TT/FT levels whereas others may feel better running lower levels.</p><p></p><p>FT 5-10 ng/dL would be considered low.</p><p></p><p>FT 16-31 ng/dL (high-end) is healthy.</p><p></p><p>Most men will do well with FT 20-30 ng/dL, some may feel better running higher levels.</p><p></p><p>Comes down to the individual.</p><p></p><p>As I stated previously most men can easily achieve a high-end let alone in many cases absurdly high FT on 100-150 mg T/week whether split twice-weekly (every 3.5 days), M/W/F, EOD let alone daily, and yes even men with highish/high SHBG!</p><p></p><p>Some may need what would be considered the high-end dose but it is far from common.</p><p></p><p>Always better to start slow and go slow as we want to see how your body reacts to testosterone.</p><p></p><p>Much easier to go up if need be than come down.</p><p></p><p>Still too high a starting dose seeing as 120 mg T every 5 days would be 168 mg T/week.</p><p></p><p>Splitting up the overall weekly dose 100-120 mg T twice-weekly (50-60 mg every 3.5 days) would be a more sensible move as you will be clipping the peak--->trough let alone have more stable blood levels.</p><p></p><p>Even then with an absurdly low SHBG injecting lower doses of T as in daily or EOD would most likely be optimal.</p><p></p><p>Using an LDS fixed U-100 insulin syringe will take care of any concerns you may have when it comes to minimizing pain/scar tissue that can be common when poking yourself with those 22-23G harpoons.</p><p></p><p>Whether injecting strictly sub-q or shallow IM using and LDS fixed insulin syringes will make a huge difference.</p><p></p><p></p><p><strong><em>I'm currently using 23g x 1.5" needles. I inject quite slowly, on purpose, but I've still been left with charlie horses for about 3 days post-injection. I'm thinking to try 27g x 1.25" needles, hoping this will help avoid post-injection pain; I know, I'm a sissy. My doctor insisted on 22g x 1.5" needles, yet the oil is easy to inject with 23g.</em></strong></p><p></p><p>Forget using the 22-23G harpoons.</p><p></p><p>If you plan on injecting strictly IM then you would be far better of using a 27G X 1"/1.25" tuberculin syringe.</p><p></p><p>Even then you can also inject shallow IM using a 27-29G X 1/2" needle length depending on where you are injecting/amount of adipose.</p><p></p><p>If you decide to inject strictly sub-q then you can easily use a 27-31G x (6MM/8MM/12.7MM needle length).</p><p></p><p>The main benefits of using LDS (low dead space) fixed insulin syringes are a minimal waste of medication (esterified T), virtually painless, minimize scar tissue/trauma, easier to read for accurate dosing especially when injecting lower volumes of oil more frequently.</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/principles-of-testosterone-and-hcg-injection-technique.20198/[/URL]</p><p></p><p></p><p><strong><em>My doctor insisted on 22g x 1.5" needles, yet the oil is easy to inject with 23g.</em></strong></p><p></p><p>Those prehistoric protocols are bad enough no need to use those harpoons even if you are only injecting once every 2 weeks.....LOL!</p><p></p><p>Let me guess.....he wanted you to take it in the butt!</p><p></p><p></p><p><strong><em>But do you think the cyp. oil will push through a 27g just fine (with 3cc barrel)? Do you think 27g would be the smallest reasonable needle, or might I even be able to get away with a 29g? I'm using BD precisionglide.</em></strong></p><p></p><p>Although big pharma cypionate uses cottonseed oil as the carrier which tends to be more viscous keep in mind that one of the excipients in the oily solution is BOH which acts as an oil viscosity reducer.</p><p></p><p>Regardless of the viscosity of the oil carrier used as some oils are more viscous than others one of the benefits of the added BOH which is a commonly used excipient in the oily solution is it acts as an oil viscosity reducer which should improve the ease of injecting.</p><p></p><p>You could always warm up the vial before drawing.</p><p></p><p>There should be no issues pushing cyp in cottonseed oil through a 27 G and if you plan on using the 27G go with a 1cc.</p><p></p><p>29G should be no issue other than it may be a little slower when drawing from the vial/injecting.</p><p></p><p>Keep in mind that 29G would be 1/2" needle length so you better plan on injecting shallow IM.</p><p></p><p></p><p>Benzyl alcohol (BOH) is a commonly used excipient in oil depots in concentrations ranging from 1.5-10% v/v and is used as a</p><p></p><p><strong>- solubility enhancer</strong></p><p><strong>- oil viscosity reducer</strong></p><p><strong>- local anesthetic</strong></p></blockquote><p></p>
[QUOTE="madman, post: 209770, member: 13851"] [I][B]Thanks for the quick and great feedback, madman! Considering I'll be having to self-inject for the rest of my life, which will hopefully be many decades longer, I'd prefer to minimize frequency, balancing this with the parallel goal of keeping levels above 500ng/dl at trough and within 1200ng/dl at peak. With this, I'm hoping to avoid frequency of more often than every 5 days; perhaps 120mg/5 days.[/B][/I] Need to get out of the mindset of getting caught up on TT. FT is what truly matters as it is the unbound active fraction of T responsible for the positive effects. Some may feel great overall with high-end trough TT/FT levels whereas others may feel better running lower levels. FT 5-10 ng/dL would be considered low. FT 16-31 ng/dL (high-end) is healthy. Most men will do well with FT 20-30 ng/dL, some may feel better running higher levels. Comes down to the individual. As I stated previously most men can easily achieve a high-end let alone in many cases absurdly high FT on 100-150 mg T/week whether split twice-weekly (every 3.5 days), M/W/F, EOD let alone daily, and yes even men with highish/high SHBG! Some may need what would be considered the high-end dose but it is far from common. Always better to start slow and go slow as we want to see how your body reacts to testosterone. Much easier to go up if need be than come down. Still too high a starting dose seeing as 120 mg T every 5 days would be 168 mg T/week. Splitting up the overall weekly dose 100-120 mg T twice-weekly (50-60 mg every 3.5 days) would be a more sensible move as you will be clipping the peak--->trough let alone have more stable blood levels. Even then with an absurdly low SHBG injecting lower doses of T as in daily or EOD would most likely be optimal. Using an LDS fixed U-100 insulin syringe will take care of any concerns you may have when it comes to minimizing pain/scar tissue that can be common when poking yourself with those 22-23G harpoons. Whether injecting strictly sub-q or shallow IM using and LDS fixed insulin syringes will make a huge difference. [B][I]I'm currently using 23g x 1.5" needles. I inject quite slowly, on purpose, but I've still been left with charlie horses for about 3 days post-injection. I'm thinking to try 27g x 1.25" needles, hoping this will help avoid post-injection pain; I know, I'm a sissy. My doctor insisted on 22g x 1.5" needles, yet the oil is easy to inject with 23g.[/I][/B] Forget using the 22-23G harpoons. If you plan on injecting strictly IM then you would be far better of using a 27G X 1"/1.25" tuberculin syringe. Even then you can also inject shallow IM using a 27-29G X 1/2" needle length depending on where you are injecting/amount of adipose. If you decide to inject strictly sub-q then you can easily use a 27-31G x (6MM/8MM/12.7MM needle length). The main benefits of using LDS (low dead space) fixed insulin syringes are a minimal waste of medication (esterified T), virtually painless, minimize scar tissue/trauma, easier to read for accurate dosing especially when injecting lower volumes of oil more frequently. [URL unfurl="true"]https://www.excelmale.com/forum/threads/principles-of-testosterone-and-hcg-injection-technique.20198/[/URL] [B][I]My doctor insisted on 22g x 1.5" needles, yet the oil is easy to inject with 23g.[/I][/B] Those prehistoric protocols are bad enough no need to use those harpoons even if you are only injecting once every 2 weeks.....LOL! Let me guess.....he wanted you to take it in the butt! [B][I]But do you think the cyp. oil will push through a 27g just fine (with 3cc barrel)? Do you think 27g would be the smallest reasonable needle, or might I even be able to get away with a 29g? I'm using BD precisionglide.[/I][/B] Although big pharma cypionate uses cottonseed oil as the carrier which tends to be more viscous keep in mind that one of the excipients in the oily solution is BOH which acts as an oil viscosity reducer. Regardless of the viscosity of the oil carrier used as some oils are more viscous than others one of the benefits of the added BOH which is a commonly used excipient in the oily solution is it acts as an oil viscosity reducer which should improve the ease of injecting. You could always warm up the vial before drawing. There should be no issues pushing cyp in cottonseed oil through a 27 G and if you plan on using the 27G go with a 1cc. 29G should be no issue other than it may be a little slower when drawing from the vial/injecting. Keep in mind that 29G would be 1/2" needle length so you better plan on injecting shallow IM. Benzyl alcohol (BOH) is a commonly used excipient in oil depots in concentrations ranging from 1.5-10% v/v and is used as a [B]- solubility enhancer - oil viscosity reducer - local anesthetic[/B] [/QUOTE]
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