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He's referring to the paper I posted above. The authors of the paper state that their study was not fully controlled, we're still awaiting further research as Nelson mentioned.

I thought you would find that interesting. In terms of awaiting further data and outcomes with TAME, I agree. I'm looking forward to reviewing data beyond what's easily measurable.

@Nelson Vergel https://diabetesjournals.org/care/article/44/12/2775/138471/Effect-of-Metformin-and-Lifestyle-Interventions-on Effect of Metformin and Lifestyle Interventions on Mortality in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study "Over a median of 21...

I'm curious as well. @Nelson Vergel I'm confused as to what the following statements meant, did it mean that two separate pharmaceutical preparations of preg. led to different level at separate blood draws? "on oral OTC pregnenolone 100 mg per day: Pregnenolone went from undetectable to 95...

*Repost from Madman, very interesting. I have polyglandular autoimmune syndrome 1 (APS-1) and is possibly why I notice such a positive improvement with exogenous GH. IGF-1 has an even greater improvements in myself. Abstract Introduction The GH/IGF-1 axis affects multiple metabolic...

Hi Nelson, Do you think it's safe to take pharmacological doses of growth hormone as you suggest 2mg to correct IGF-1 deficiency? Have you considered the use of IGF-1 therapy in which case? I'm aware of growth hormone 2mg for specified indications, but for long-term HRT I think it may be safer...

If you are unable to stimulate the liver to produce IGF-1 from GH, you may consider IGF-1 therapy. Use a combination of exogenous growth hormone and IGF-1 to correct GH and IGF-1 deficiency. IGF-1 produces roughly 60% of the beneficial effects of growth hormone so you may consider correcting...

Hi Nelson, Have you tried this combination yet? If so, did you experience a decrease in muscle pumps or experience any fatigue? Generally, what was your experience? thanks for your response in advance!

I'm a big fan of the evidence for semaglutide and have recently started taking it for personal researching. I may consider combining with canagliflozin once I get a feel for long-acting GLP-1. I will report back.

Hi Nelson, I have tried this combination and found that I gained muscle and I believe your suspicions are correct, you will not lose your muscle pump or mass, as I did not. The muscle sensitizing effect on muscle seems to be profound in my case, subjectively speaking. My pre-existing concerns...

Hi Nelson, May I ask if you have any updates on your experience with tesamorelin? Have you had your IGF-1 levels determined?

Hi there, You mentioned your IGF-1 levels tripled, may I ask what your IGF-1 serum was before and after your trial? Are you currently taking it? If so what are your levels at these days if you have had them checked? I appreciate your response in advance.

The conboy study showed a substantial reversal of epigenetic aging over the TRIM. https://joshmitteldorf.scienceblog.com/2020/06/08/out-with-the-old-blood/

Hi there, thanks for sharing your experience. What aging tests did you have performed ie. Telomere, epigenetic? Epigenetic aging essentially measures damage that comes with aging so we think that the reversal of age seen in the TRIM study was to do with the increase in size of the thymus...

Nir Barzilai studies centenarians and has found that lower IGF-1 levels in females improve cognitive function and extend lifespan. It has shown to be the opposite in males, not extending lifespan. https://www.amazon.com/Age-Later-Health-Science-Longevity/dp/1250752582...

Nelson, What are your personal thoughts on growth hormone and IGF-1 for longevity?

The Effects of Resveratrol Intake on Weight Loss: A Systematic Review and Meta-Analysis of Randomized Controlled Trials “Resveratrol supplementation significantly decreased body weight in obese patients (SMD -0.43; 95% CI, -0.60, -0.26) compared with other diseases (SMD 0.02; 95% CI, -0.29...

I agree, it’s the safest and most effective secretagogue! I’m glad your seeing great results with your IGF-1 levels :)

What I meant was that patient case studies don’t show significant improvements in sleep or pronounced subjective mood improvements compared to that of CJC 1295. Regardless, it’s far more effective at raising IGF-1 of an average of 181 points without raising fasting insulin. Very interesting...

Hi there, thanks for your reply! May I ask your current dosing regime? That’s a great achievement and successful outcome. Tesamorelin typically doesn’t lead to significant, subjective benefit as indicated by anecdotal reports and compared to other GHRH secretagogues. I’m glad to hear of your...

Hi Nelson, Do you have any updates with your experience with tesamorelin? Have your had any labs done such as metabolic parameters and endocrine such as IGF-1? Thanks for your time!

Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin Abstract Myotonic dystrophy type 1 (DM1; MIM #160900) is an autosomal dominant disorder, clinically characterized by progressive muscular weakness and multisystem...

You got it all figured out. You aren't educated so you can't read the literature to have a deep understanding. Good luck!

Cataceous, I first gave you an article that cited numerous studies and you have not done your homework. It's clear you do not have a background in bioscience as you do not know how to debate. I added that video because you are at the level of which it would be beneficial for you to hear from a...

The research simply is not in support of your belief. A balance of mTOR and AMPK is important for healthspan and longevity. Listen in at Rhonda Patrick at 5:45. #02 - Rhonda Patrick, Ph.D.: the performance and longevity paradox of IGF-1, ketogenic diets and genetics, the health benefits of...

LOL, you are a Valter D. Longo fan, now I understand your position. Valter doesn't believe in anything but supporting aging through lifestyle factors. I respect Valter, though the 2011 study you posted is one of four that are published by him supporting IGF and cancer risk and there are roughly...

"Data on the IGF-1 system in relation to longevity are still controversial in long-lived subjects. One team described an increased plasma IGF-1/IGFBP-3 ratio in healthy centenarians compared to elderly subjects. They hypothesized that this elevated ratio was indicative of a higher IGF-1...

That's a great hypothesis. You might as well not take any hormones so your within your age lab ranges as you age. Testosterone, DHEA, preg, progesterone, thyroid lol. You might as well not restore AMPK to youthful levels either. Please read this article, all studies are cited. Lifespan Journal...

For an averaged sized man 300-350µ/l/ml. Under 200 is associated with an increased risk of mortality. That level for an averaged sized man is associated with optimal quality of life and health span. The benefits are shown of many, age reversal of physical signs of aging and greatly improves...

LOL, it's like you read my mind! Aw well, I'm interested hearing your results. I'll follow up soon with my labs as well.

Yikes. Have you preformed a stimulation test? Growth Hormone and IGF-1 would be best in your situation. .9mg of growth hormone and .09 of IGF LR3 may work best in your situation.