How to Lower Hematocrit Using Grapefruit Seed Extract Naringin
- Thread starter Bennytrt
- Start date
My HCT is usually in the high 40's to low 50's. I've been taking Naringin (Grapefruit Seed Extract) for awhile. In my consult with Defy, they recommend it.
I also recently started Nattokinase. It is a blood thinner and some say that it also lowers HCT.
I just had my labs done, so I'll know more soon.
Metformin is also supposed to lower HCT. I take it daily.
HCT is an issue for me because I live at a mile high altitude. Dehydration is also a factor for me as I am in the high desert. I've never donated blood.
I also recently started Nattokinase. It is a blood thinner and some say that it also lowers HCT.
I just had my labs done, so I'll know more soon.
Metformin is also supposed to lower HCT. I take it daily.
HCT is an issue for me because I live at a mile high altitude. Dehydration is also a factor for me as I am in the high desert. I've never donated blood.
Last edited:
Vince
Super Moderator
To lower HCT, some members eat a 1/2 of grapefruit
www.medicinenet.com
Can Grapefruit Juice Interact with Medications and Drugs?
Grapefruit juice can interact with drugs. Find out if the medication you are taking is at risk of a drug interaction with grapefruit juice. Examples of drugs include statins, pain medications, calcium channel blockers, and antihistamines.
www.medicinenet.com
How many mg's are you consuming of GSE? Did it help you maintain your HCT between the ranges you mentioned? I have my consult with Defy tomorrow and I will ask them how much they recommend to take.
Hmmm..nattokinase, huh? I will look into that as well. How much of that are you taking?
I did not know metformin helps to also thin the blood. I will also mention that. I take berberine hcl with hydroxypropyl beta cyclodextrin at a 1:1 ratio.
I don't want to donate blood again since my iron is at 75. My HCT is at 53.3 and that's because of nandrolone. I usually sit between 50 and 52 for my HCT.
Dehydration is also a big factor. I forget the ratio, but there is a ratio between HCT and your red cell blood count to determine if you are dehydrated. You can google it. Typically, I am a bit dehydrated as I live in the desert.
I was taking 1000 mg of Narigin each morning but upped it to 1500. I did help maintain my levels, albeit still considered too high by some.
Yes, dehydration is a big factor but not for me. I drink 1.5 to 1.75 gallons of water per day. Before I get my labs done I drink slightly more than half a gallon of water.
I will take 1000 mg of gse and see what happens. I will test my HCT in a week to see if it has helped or not. Hopefully that's long enough to notice results. Yeah, you're levels and mine are considered high for a few people out there. Thanks for the dose information.
How much nandrolone have you added to your protocol to cause that increase in hematocrit?
I was considering this but grapefruit(naringin) can interfere with the absorption of too many oral medications, they continually add more and more every year. don’t take it if you use viagra or cialis
it also interferes with the metabolism of estrogen.
www.everydayhealth.com
it also interferes with the metabolism of estrogen.
Grapefruit Guide: Nutrition, Benefits, Side Effects, and More
How many calories are in grapefruit? What does the fruit offer in terms of nutrition? Find out the answers to FAQs about grapefruit in this detailed guide on how to use the fruit (as well as grapefruit seed and grapefruit seed extract!) and reap the benefits.
www.everydayhealth.com
Nelson Vergel
Founder, ExcelMale.com
Curcumin to Lower Hematocrit ?
Saw the thread a few weeks back regarding a cancer patient that took curcumin to relieve his arthritis while undergoing chemo. His hemoglobin dropped a few points in a short period. So being the lab rat that I am, and having some pretty juicy hct numbers, I had to see for myself. Let me start...
www.excelmale.com
The appropriate dose of naringin to lower hematocrit levels is not definitively established, but several studies and sources provide some guidance on effective dosages and their safety.
- Study on Grapefruit Ingestion: A study involving the ingestion of grapefruit, which contains naringin, showed that consuming half to one grapefruit per day significantly lowered hematocrit levels in human subjects over a 42-day period. The decrease in hematocrit was statistically significant at the p < 0.01 level, indicating a strong effect.
- Supplementation Studies: Naringin supplements are available in various dosages. For instance, a safety and pharmacokinetics study found that doses ranging from 150 mg to 900 mg of naringin were safe for healthy adults, with serum concentrations proportional to the dose administered. This suggests that a dose within this range could be effective and safe.
- General Recommendations: Some sources recommend a daily dose of naringin in the range of 40 to 80 mg/kg body weight for various health benefits, including its potential to lower hematocrit levels. This dosage can vary based on individual factors such as age, weight, and overall health.
- Commercial Supplements: Commercially available naringin supplements, such as those from Swanson, typically come in 500 mg capsules with a recommended dosage of one capsule twice per day. Another product suggests a daily intake of 600 mg, divided into two doses of 300 mg each.
Citations:
[2] Ingestion of grapefruit lowers elevated hematocrits in human subjects - PubMed
[3] Safety and Pharmacokinetics of Naringenin: A Randomized, Controlled, Single Ascending Dose, Clinical Trial
[4] https://www.scielo.br/j/bjps/a/QCq7fk6CszPnvHNr7RfFWCG/?format=pdf&lang=en
[5] https://www.osmosis.org/answers/hematocrit
[6] Comprehensive Guide to Manage High Hematocrit Levels in Testosterone Replacement Therapy
[7] What Does a High Hematocrit Result Mean?
[8] How to Lower Hematocrit Levels (with Pictures) - wikiHow
[9] Erythrocyte Storage Lesion Improvements Mediated by Naringin Screened from Vegetable/Fruit Juice Using Cell Extract and HPLC-MS
[10] Amazon.com
[11] Naringin: An Antioxidant Flavonoid Against Cellular Aging - nutriavenue.com
[12] Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects - PubMed
[13] https://rjptonline.org/HTMLPaper.as...l+of+Pharmacy+and+Technology;PID=2019-12-1-67
[14] https://us.supersmart.com/en/shop/anti-aging/grapefruit-extract-naringine-supplement-0724
[15] https://rjptonline.org/HTML_Papers/...armacy and Technology__PID__2019-12-1-67.html
[16] https://www.amazon.com/Swanson-Naringin-500-Milligrams-Capsules/product-reviews/B0017OFS0K
[17] https://www.amazon.com/SUPERSMART-Grapefruit-Vegetarian-antibiotic-Properties/dp/B07JZ3Q4B4
[18] https://www.researchgate.net/public...o-Pathological_Variations_in_Male_Wistar_Rats
[19] https://www.sciencedirect.com/science/article/abs/pii/S2210523913000664
[20] https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/naringin
Nelson Vergel
Founder, ExcelMale.com
Can Losartan decrease high hematocrit caused by testosterone replacement?
Recently I had a really bad cold with a severe cough. It was so bad my doc put me on a bunch of stuff to reduce inflammation in my Bronchial and some cough trigger pills. He also had me stop using Lisinopril. It's one side affect in a drip and cough. I didn't take Lisinopril for BP, I toke it...
www.excelmale.com
Nelson Vergel
Founder, ExcelMale.com
How to Lower High Hematocrit Caused by Testosterone Replacement Therapy (TRT)
High Hematocrit Caused by Testosterone Replacement Therapy By Nelson Vergel, B.S.Ch.E., M.B.A. High hematocrit occurs when there is an excessive production of red blood cells. High hematocrit can cause the blood to become very viscous or "sticky," making it harder for the heart to pump. High...
www.excelmale.com
Can Losartan decrease high hematocrit caused by testosterone replacement?
Recently I had a really bad cold with a severe cough. It was so bad my doc put me on a bunch of stuff to reduce inflammation in my Bronchial and some cough trigger pills. He also had me stop using Lisinopril. It's one side affect in a drip and cough. I didn't take Lisinopril for BP, I toke it...
I hear if you get sick white blood cells increase and that lowers your RBC.
0.06ml everyday. I just added lactoferrin and doubled my dose with tudca to control the production of RBC
Nelson Vergel
Founder, ExcelMale.com
Ingestion of grapefruit lowers elevated hematocrits in human subjects
Robbins, R C ; Martin, F G ; Roe, J M
International journal for vitamin and nutrition research, 1988, Vol.58 (4), p.414
This study was based on in vitro observations that naringin isolated from grapefruit induced red cell aggregation and evidence that clumped red cells are removed from the circulation by phagocytosis. The effect on hematocrits of adding grapefruit to the daily diet was determined using 36 human subjects (12 F, 24 M) over a 42-day study. The hematocrits ranged from 36.5 to 55.8% at the start and 38.8% to 49.2% at the end of the study. There was a differential effect on the hematocrit. The largest decreases occurred at the highest hematocrits and the effect decreased on the intermediate hematocrits; however, the low hematocrits increased. There was no significant difference between ingesting 1/2 or 1 grapefruit per day but a decrease in hematocrit due to ingestion of grapefruit was statistically significant at the p less than 0.01 level.
Robbins, R C ; Martin, F G ; Roe, J M
International journal for vitamin and nutrition research, 1988, Vol.58 (4), p.414
This study was based on in vitro observations that naringin isolated from grapefruit induced red cell aggregation and evidence that clumped red cells are removed from the circulation by phagocytosis. The effect on hematocrits of adding grapefruit to the daily diet was determined using 36 human subjects (12 F, 24 M) over a 42-day study. The hematocrits ranged from 36.5 to 55.8% at the start and 38.8% to 49.2% at the end of the study. There was a differential effect on the hematocrit. The largest decreases occurred at the highest hematocrits and the effect decreased on the intermediate hematocrits; however, the low hematocrits increased. There was no significant difference between ingesting 1/2 or 1 grapefruit per day but a decrease in hematocrit due to ingestion of grapefruit was statistically significant at the p less than 0.01 level.
would the grapefruit interfere with losartan? or carvedilol?To lower HCT, some members eat a 1/2 of grapefruit
Can Grapefruit Juice Interact with Medications and Drugs?
Grapefruit juice can interact with drugs. Find out if the medication you are taking is at risk of a drug interaction with grapefruit juice. Examples of drugs include statins, pain medications, calcium channel blockers, and antihistamines.
Vince
Super Moderator
Yes
I know grapefruit can interfere with viagra and cialis by extending its duration in your system… is this really a bad thing? a longer half-life sounds ideal…. @Nelson Vergel your thoughts too please.
Vince
Super Moderator
Grapefruit juice blocks special enzymes in the wall of the small intestine that actually destroys many medications and prevents their absorption into the body. Thus, smaller amounts of the drugs get into the body than are ingested. When the action of this enzyme is blocked, more of the drugs get into the body and the blood levels of these medications increase. This can lead to toxic side effects from the medications.
www.medicinenet.com
Can Grapefruit Juice Interact with Medications and Drugs?
Grapefruit juice can interact with drugs. Find out if the medication you are taking is at risk of a drug interaction with grapefruit juice. Examples of drugs include statins, pain medications, calcium channel blockers, and antihistamines.
www.medicinenet.com
Grapefruit juice blocks special enzymes in the wall of the small intestine that actually destroys many medications and prevents their absorption into the body. Thus, smaller amounts of the drugs get into the body than are ingested. When the action of this enzyme is blocked, more of the drugs get into the body and the blood levels of these medications increase. This can lead to toxic side effects from the medications.
Can Grapefruit Juice Interact with Medications and Drugs?
Grapefruit juice can interact with drugs. Find out if the medication you are taking is at risk of a drug interaction with grapefruit juice. Examples of drugs include statins, pain medications, calcium channel blockers, and antihistamines.
I understand how it generally effects medications and I’ve researched it specifically for viagra: I guess I should’ve asked, what do you guys think would be the greatest danger?Grapefruit juice blocks special enzymes in the wall of the small intestine that actually destroys many medications and prevents their absorption into the body. Thus, smaller amounts of the drugs get into the body than are ingested. When the action of this enzyme is blocked, more of the drugs get into the body and the blood levels of these medications increase. This can lead to toxic side effects from the medications.
Can Grapefruit Juice Interact with Medications and Drugs?
Grapefruit juice can interact with drugs. Find out if the medication you are taking is at risk of a drug interaction with grapefruit juice. Examples of drugs include statins, pain medications, calcium channel blockers, and antihistamines.
“Conclusions: Grapefruit juice increases sildenafil bioavailability and tends to delay sildenafil absorption. Sildenafil pharmacokinetics may become less predictable with grapefruit juice. Although patients usually will not be endangered by concomitant use of grapefruit juice, it seems advisable to avoid this combination.”
Effects of grapefruit juice on the pharmacokinetics of sildenafil - PubMed
Grapefruit juice increases sildenafil bioavailability and tends to delay sildenafil absorption. Sildenafil pharmacokinetics may become less predictable with grapefruit juice. Although patients usually will not be endangered by concomitant use of grapefruit juice, it seems advisable to avoid this...
pubmed.ncbi.nlm.nih.gov
GreenMachineX
Well-Known Member
I've been looking for info on grapefruit extract and telmisartan because I'd like to get it for hct as well, but haven't found anything concrete.I understand how it generally effects medications and I’ve researched it specifically for viagra: I guess I should’ve asked, what do you guys think would be the greatest danger?
“Conclusions: Grapefruit juice increases sildenafil bioavailability and tends to delay sildenafil absorption. Sildenafil pharmacokinetics may become less predictable with grapefruit juice. Although patients usually will not be endangered by concomitant use of grapefruit juice, it seems advisable to avoid this combination.”
Effects of grapefruit juice on the pharmacokinetics of sildenafil - PubMed
Grapefruit juice increases sildenafil bioavailability and tends to delay sildenafil absorption. Sildenafil pharmacokinetics may become less predictable with grapefruit juice. Although patients usually will not be endangered by concomitant use of grapefruit juice, it seems advisable to avoid this...
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