Anabolic steroids and TRT decrease SHBG, DHEA, pregnenolone and progesterone in men.

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@Nelson Vergel
What about HMG instead of HCG?

My reply from another thread: HMG to HCG IU equivalency?

Most would never use hMG as a sole replacement to substitute LH.

hCG is used as it mimics LH which stimulates the Leydig cells in the testes to produce ITT (intra-testicular testosterone) and hMG or rhFSH would be added (@75-150 IU 3 X weekly) as the main reason would be to stimulate Sertoli/germ cells.

Could you imagine the dose/cost needed to use hMG as a sole replacement not to mention other issues it may cause!


*Human menopausal gonadotropin contains both LH- and FSH-activity. However, a dose that provides adequate FSH activity does not maintain Leydig cell function because the LH-activity is low. Thus a combination with hCG is required to achieve fertility.





 
My reply from another thread: HMG to HCG IU equivalency?

Most would never use hMG as a sole replacement to substitute LH.

hCG is used as it mimics LH which stimulates the Leydig cells in the testes to produce ITT (intra-testicular testosterone) and hMG or rhFSH would be added (@75-150 IU 3 X weekly) as the main reason would be to stimulate Sertoli/germ cells.

Could you imagine the dose/cost needed to use hMG as a sole replacement not to mention other issues it may cause!


*Human menopausal gonadotropin contains both LH- and FSH-activity. However, a dose that provides adequate FSH activity does not maintain Leydig cell function because the LH-activity is low. Thus a combination with hCG is required to achieve fertility.





Local X-Ray department fried my Leydig cells via excessive X-ray exposure ‍♂️
19 Pelvic in one day, ~ 60 of them in total over a 20 year period… just turned 46 last week.
I’m done…
 
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