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BPC-157 has some kind of dopamine blocking effect that can cause anhedonia / depression in susceptible individuals. In some cases it can be quite serious.

I don't remember, but if you're specifically trying to prevent iron absorption I think you'd want to take it with meals, especially meat.

He speaks the truth.

Wtf? That's crazy high. I think you need to do something to bring it down. I was taking an IP6 supplement at one point and that crashed my ferritin very quickly. You could also donate blood.

This is a sloppy conclusion. It's fine to report that your knees stopped aching after 3-4 BC pills. It's not fine to confidently state the mechanism was boosted cortisol, unless you measured that, which you didn't. Actually, even if you had documented elevated cortisol, you still wouldn't know...

I suspect negative effects may be due to the way BB affects the release of testosterone from the oil depot. It causes a big spike of release in the beginning that you don't have otherwise. There's a paper called "New Insights In Drug Absorption From Oil Depots" that has great info on that if...

On most Saturday mornings I bring my family to a local breakfast place where I will eat a meat lover's omelet with three eggs. Occasional consumption like that seems fine. It's when I try to make eggs a daily staple that I get in trouble.

I do get a depressed mood if I eat too many eggs too consistently. For example, if I do something like 3 eggs a day for a week or more. It doesn't cause the extreme overstimulation, anxiety and insomnia that I experienced on the BB/BA containing formulas though.

Have you tried enanthate yet?

Cream is similar to propionate in terms of the degree of fluctuation across the day but the ratio of hormones it produces is quite different. You might respond better to the more physiologic DHT/E2 ratio of propionate versus the heavily DHT-skewed ratio with cream. If you wanted to make the...

I think enanthate is the only ester that will dissolve readily in oil at reasonably high concentrations. They need to add benzyl benzoate as a solvent to assist other esters like cypionate and propionate. It may be the case, for example, that without BB in the formula, you would max out at 50...

Nothing you can't fix with the right mix of bioidentical hormones. Of course you'll want to do that anyway for the prevention of neurodegenerative disease, osteoporosis, CVD, and frailty. The restoration of youthful sexuality is a nice side benefit though.

I use the omron model where the control panel and machine is integrated with the cuff. My research suggested that was more accurate and durable than alternatives. The units with the separate box connected to the cuff by a tube often break. It works great for me...

I'm hesitant to suggest it but have you thought about trying something like amitryptyline for this to see if it is more of a hypersensitivity thing rather than a physical problem? There are many positive anecdotes treating functional dyspepsia with amitryptyline. Just an idea that may not have...

I don't think it is that unusual. "Healthy food" generally means whole plant foods to most people, which are fibrous, full of enzyme inhibitors, anti-nutrients, and generally quite challenging to digest. What are we really doing when we process food? Besides increasing shelf-life or...

Another anecdote of higher T and less aromatization after switching from SC to IM: https://www.reddit.com/r/trt/s/En5dBX6JBu

You make a bunch of good points as usual. I would personally be hesitant to make changes to a protocol described as "dialed-in, "life changing," and has delivered consistent results over a relatively long period of two years. Yes, check your HCT, lipids, blood pressure, etc, and read up on the...

I wouldn't drop more than that, just wait and see what happens with 100 mg. You will be in a bit of a withdrawal state now from the higher dose and you need to get to the other side of that before you know how 100 mg will treat you. Madman will jump in at some point and tell you any conclusions...

That's a reasonable idea, and 50 mg twice weekly is about is good as it gets for starter protocols. However, you would be changing two variables there at once, which you generally don't want to do. Increasing frequency is usually helpful for reducing side effects, but not typically for...

Much like the vegan to carnivore versus carnivore to vegan transitions, cypionate vs. enanthate has a very lopsided preference ratio. Among people that have tried both, many do not have a preference. However, when someone DOES have a preference between those two esters, the ratio is 10:1...

I'm sure he didn't mean to imply that - Hikma enanthate is liquid gold and it is God's gift to TRT users. I've tried maybe ten different formulas now and I am not kidding with you. If you are having good results with delatestryl, why would you want to switch to a different ester and a...

I think you are more likely to get away without E2 management on scrotal cream than other forms of TRT. The astronomical DHT levels may inhibit aromatase and/or antagonize estrogen effects in tissues.

I think more important than naming a specific number is just understanding that such a number exists. In other words, for most guys, there is some threshold E2 level beyond which your erections will suffer. Once you have that idea in mind, you can work on figuring out what your personal...

Absolutely. Forget the mainstream dietary prescriptions derived from sloppy epidemiology and try everything yourself. Try a Mediterranean diet, try a whole-food plant-based diet (healthiest version of veganism), try a paleo diet, try a carnivore diet. Look at your symptoms, look at your...

Yes, very helpful. I've known BD has the best insulin syringes but it has been difficult to find a place that carries them and will ship to Connecticut without a prescription. Thanks @madman.

I don't really want to evaluate anything at the moment because I just changed things drastically. Since discovering the AI is the world's most effective BP and sleeping medication, I bumped my dose back to the 50 mg EOD and am going to see what happens with that. My mental health in terms of...

Not having any major problems with acne. I think high E2 contributes to oily skin and acne as well. Seems to be improved with AI.

Don't take it on faith. Try it and see for yourself.

Nothing against sardines -- if you like them, they're better for your health than any plant food. The problem is the premise that red meat is problematic for health and needs to be swapped out for anything else. In fact, the more red meat you eat, the healthier you'll be, right up to and...

Were you smoking during your trials of TRT? That could have really messed you up. It's estrogenic and makes estrogen management, which I have a newfound appreciation for, much more challenging. Especially when we are talking about high BP and heart rates -- these are symptoms I've seen respond...

This is one of the two big reasons I never touch weed. It slows gut motility dramatically and makes everything worse: constipation, reflux, gastritis, etc. Absolutely needs to go if you struggle with any of those issues. The other big reason is the depressive rebound after effects. I find all...