SHBG High

[sr101]

Hello,

I wounder if anyone can offer any advice, I am 46 years old and seem to have a lot of symptoms that relate to low testosterone, is there anything to worry about in my lab tests? I see SHBG levels are high is this something to be concerned about?

Albumin levels are 45 g/L, so total free test is looking like 0.245 nmol/L = 1.35 % and Bioavailable Testosterone is 5.99 nmol/L = 33.1 %.

Testosterone 18.10 nmol/L
Luteinizing Hormone 4.7 IU/L
DHEA-S 5.90 umol/L
Oestradiol 78 pmol/L
Sex Hormone Binding Globulin (SHBG) 62 nmol/L
Follicle stimulating hormone (FSH) 3.3 IU/L
Prolactin 134 mIU/L
Vitamin B12 123 pmol/L

thanks

 

[Systemlord]

so total free test is looking like 0.245 nmol/L = 1.35 % and Bioavailable Testosterone is 5.99 nmol/L = 33.1 %.

Your free testosterone is low. 2-3% free testosterone is normal. You’re just above the cut off level. The normal ranges are poorly established, and have nothing to do with quality of life.

Many experts argue that free testosterone in the bottom 25 percentile is a sign of hypogonadism.

I see SHBG levels are high is this something to be concerned about?

Androgens, testosterone suppresses SHBG, so it’s not uncommon to see high SHBG alongside low free testosterone. The first things that happens when a man goes on TRT is the SHBG goes down.

 

[sr101]

Thanks alot for your reply, I thought it was low and just above the cut off point so would explain why I am seeing many of the low T symptoms. I will ask the doctor to refer me to discuss this further.

 

[Systemlord]

Thanks alot for your reply, I thought it was low and just above the cut off point so would explain why I am seeing many of the low T symptoms. I will ask the doctor to refer me to discuss this further.

I wouldn’t expect much from your doctor or your medical system, sex hormones is a field of medicine many doctors just don’t understand.

Men have different types of androgen receptors and sensitivities at those receptors, different receptor density, as well as the abilities for tissues to respond.

Everyone has their own normal range, but doctors treat everyone exactly the same.

I fully expect your doctor to look at you like a deer in headlights if you try to explain any of this to him.

 

[NewGuy1DB]

First post and questions. First I would like to thank the contributors and organizers of this forum--it has been a valuable resource educating me on the subject of mens health.
Now the questions posted here as I have similar questions as the OP.
Seventy four years old, 45 years weight training, and showing all the symptoms of low T to include ED, suppressed mood, low energy/motivation, and loss of lean body mass. Talked with my doctor, had some blood work done (used info on this forum to add to his labs list) and received the results yesterday. Total T is 586 but Free T is 5.3 (less than 1% of Total T), SHBG is 58, Albumin is 4.4, Hematocrit is 49 (I live at 6k ft elevation if that matters-it varies from 46 to 49), Estradiol (sensitive) is 23.6, and LH and FSH are high at 12.2 and 14.1 respectively (primary hypogonadism). At my next Dr's visit I intended to press to start a protocol of 80 mg Test E per week split into two 40 mg injections per week--however I expect him to suggest that due to my Total T of 586 he would recommend nothing--even though I have all the traditional low T symptoms. Do you think the protocol I am suggesting could push my Free T up into the 2-3% of Total T range?? Would it push my Total T too high?? I just want to feel better!!