All of the stem cell therapies are scams. While there's been great progress in taking adult cells and converting them to pluripotent stem cells, there's huge problems on the delivery side of things. Once injected in the body, there is no way to guide the differentiation of the stem cells. You want them to become chondrocytes, but there's nothing that's going to signal the stem cells to differentiate into chondrocytes. Most of the stem cells just end up dying. Even if researchers solve the differentiation problem, there is a secondary and much bigger problem. Once injected into the body, the stem cells don't stay where they are injected. They can migrate to anywhere. Right now this isn't a problem because they don't differentiate. But if you can signal them to differentiate into chondrocytes, then you get the problem of chondrocytes in places you don't want them, like in heart tissue. I'm pretty pessimistic that stem cells will ever be a viable therapy for any condition.
boneandjoint.org.uk
@Cataceous places like this know people like you and me will spend what ever money we have to, to avoid surgery and quit having pain. It honestly make me angry to see older guys being taken advantage of. When I had to be turned over to a sales associate, I felt like I was buying a used car or something. Sorry you wasted you money. I still have the jury out on this HG thing. I want to see how long this lasts. At $100 a kit for hGH I could buy quite a bit of hGH for what they want for 1 Regenexx treatment. I still have the other shoulder, the knee and low back to deal with.
www.sciencedirect.com
www.excelmale.com
Seems like the key phrase I keep seeing in all of these solutions is "stimulating IGF-1 production." Perhaps intra-articular injections of IGF-1 would be a good idea?Effects of intraarticular treatment with stanozolol on synovial membrane and cartilage in an ovine model of osteoarthritis
Aim of the study was to verify the clinical and morphological effects of intra-articular stanozolol or placebo treatment, lasting 3 and 9months, in sh…
Stanozolol on HRT
Gents- As a kid I enjoyed Dianabol and especially Anadrol. I'm not into the Grey and Black market these days as I'm 38 and top old for that BS. My doc only offers 2 oral [in the title]. I never tried Var bc it's often faked but of course the pharmacy will he real. Still it's very expensive...
I will report back if I ever try it.
Commercial product...
www.excelmale.com
www.theguardian.com
www.nature.com
www.sciencedirect.com
ker.com
paulickreport.com
www.ncbi.nlm.nih.gov
That's as interesting idea, as is stanozolol (and while we're at it, it would be interesting to see if nandrolone had a synergistic affect under the conditions you're creating.) If I understand the creation of IGF-1 through the liver correctly, the IA injections would create an IA GH spike but not an IGF-1 spike, so both might by helpful.
I purchased from Precision Peptides whom I found through this sites forums and have been taking it now for 1 week.. Out of all the research I have done and all the good I've heard about bpc157 this now leaves me in question to your theory on it's "healing" properties... I have horizontal and vertical tear on left side meniscus on my right knee. The MRI shows "complex tear" surgeons words it's mangled.. She could not give me a good answer when I asked what would you do.. In the end she felt like surgery was best.. Now, I left saying ok because I could hardly walk without crutches and already 1month in from when it tore on October 2.yea def try to avoid surgery unless you you cannot stand it and wait 6 more months. know so many guys who saw the awesome young and very rich sports dr who loved giving surgery to anyone he could.. they thought because dr said lets do it it meant it would help... lol more so they make the big bucks in the OR.. and that bit sore shoulder they wish to have back as spent years and years recovering from surgery to get near the old normal pain/movement wise..
I would like to make a note about BPC and TB peptides... just so folks are aware. yes BPC will help pain, however its mechanism of action isn't what you may assume... that is to say, the "healing" isn't healing rather feeling better (which is great), BPC acts on the brain like anti depressants also BPC has a similar side effect profile..flat mood, stimulants work less etc... but also "healing" of broken bones in animals and tendon bone healing is also found in animals(like BPC) with prozac... so the folks who studied the peptides mirrored studies already done by other antidepressants that had shown healing in animals.. as it turns out the "healing" in animals was because under less stress/pain and they moved around less as less social stress... antidepressants are also Rx for pain... something to keep in mind, may not "heal" like u think just feel better. also it seems people who have history of anxiety or depression tend to be the ones who felt BPC "healed" there torn tendon in a week(which of course is not possible), feeling less pain in a day or 2 is though..
TB can increase bodies immune response which sounds great, however if covid taught us anything its that over stimulated immune response with high levels of cytokinins which can cause inflamation over active immune responses. so if take TB def dont take it if recently had covid, may get more antibodies which again is sorta nice but they are also what causes alot of the damage from covid aswell as the vaccine.. that is to say just because a study hasn't looked into long term use or even side effects of whatever peptide doesn't mean they dont exist even if blogs from clinics make it seem otherwise. so proceed with caution with peptides. kind of scares me when people get allergic reaction to TB or thyma 4 and the naturopathy folks say its "detox" and keep using..
EDIT:
im sure other things are happening and perhaps not binary however side effect profile and effect just appear to mirror antidepressants so very closely and of course BPC has been studied for its antidepressant properties. I have little doubt that people get relief and that in and of itself is remarkable never mind if help heal aswell! I just would be wary of long term use. would be interesting if cat or dog saliva holds such healing gastric peptides like BPC...
im sure this bone tendon healing study sounds familiar to the BPC folks
or
Selective Serotonin Reuptake Inhibitor Promotes Bone-Tendon Interface Healing in a Rotator Cuff Tear Rat Model - Tissue Engineering and Regenerative Medicine
Background: Selective serotonin reuptake inhibitor (SSRI) is believed to accelerate wound healing, and thus expected to have a positive effect on rotator cuff repair. We hypothesized that SSRI has a positive effect on the healing of the bone-tendon interface (BTI), and improved rotator cuff tear...link.springer.com
Histologic and Biomechanical Evaluation of the Effects of Social Stress and the Antidepressant Fluoxetine on Tendon Healing in Rats
Thieme E-Books & E-Journalswww.thieme-connect.com
antidepressants heal bone fractures.... sound familiar?
Effects of social stress and fluoxetine treatment on fracture healing in a rat femur fracture model
Mental stress and depressive disorders have negative effect on bone biology and increase fracture risk. Fluoxetine is a widely used selective serotoni…
antidepressants heal peptic ulcers...
Tricyclic Antidepressant Therapy for Peptic Ulcer Disease
• The role of tricyclic antidepressants (TCAs) as agents for treatment of peptic ulcer disease is of growing interest. In both placebo-controlled clinical trials and comparative studies with cimetidine, TCAs have proved effective and safe as ulcerhealing agents. The mechanism of action by which...jamanetwork.com
what's interesting is that BPC was found to reduce serotonin syndrome... one would think it would just be lowering serotonin or at least stopping its release?? or counteracts the drug given to induce SS... SS btw can be caused by antidepressants. imagine may be why some people get "flat mood" /anhedonia/caffiene or ADHD meds stop working from BPC-157.
make sure u get real stem cells if actually want best chance to work, and not the concentrated blood.
omegas and at least a small dose of quality protein mix and fibre, hemp seeds flax seeds 2 tablespoons a day keeps intestines happy and omegas/protein is wonderful, nails hair eyes skin all get nicer/stronger, have to assume helps internals stay lubricated/less inflamed too. aminos with nutrient dense food/vitamins seems to really have a synergy and guess it has to do with chelation to drive nutrients into your body and help growth and healing.
stay away from iron supplements unless deficient as promotes oxidation/inflammation.
