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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
AGE SPECIFIC CALCULATED FREE TESTOSTERONE RANGES IN ADULT MEN
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<blockquote data-quote="madman" data-source="post: 279569" data-attributes="member: 13851"><p>Even then we need to wait on harmonized FT reference ranges based on a standardized FT assay (ED-LC/MS/MS).</p><p></p><p>Similar to what was done for harmonized TT.</p><p></p><p><strong><em>*Assays that are <u>standardized are designed to provide accurate results, traceable to “true” value-assigned certified reference materials and gold-standard reference methods</u>.</em></strong></p><p></p><p>The CDC has been working hard on this and it is not too far off now!</p><p></p><p>Soon enough we will have a CDC Hormone Standardization Program (CDC HoSt) Certified Free Testosterone Procedure and a harmonized reference range for free testosterone!</p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/threads/cdc%E2%80%99s-clinical-standardization-programs-cdc-csp-ensuring-the-accuracy-and-reliability-of-chronic-disease-biomarker-tests.30192/[/URL]</p><p>[ATTACH=full]43656[/ATTACH]</p><p></p><p></p><p></p><p></p><p>Something to keep in mind when it comes to using/relying upon the calculated FT methods!</p><p></p><p><strong><em>*Currently, the CDC is developing a <u>harmonized method for free T based on calculated free T using REVISED FORMULAE.</u> This may bring the measurement of free T to a <u>referable standard</u> in clinical laboratories and <u>common reference intervals</u> that all clinicians can use</em></strong></p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/threads/how-to-co-relate-ria-and-equilibrium-dialysis-reports.30209/#post-278995[/URL]</p><p></p><p>Take home points:</p><p></p><p><em><strong>*Assays that are <u>standardized are designed to provide accurate results, traceable to “true” value-assigned certified reference materials and gold-standard reference methods</u>. <u>Results obtained using standardized methods can be compared across assays, institutions, populations, and past and future test results, thereby improving diagnosis, treatment, and outcomes of patients</u></strong></em></p><p></p><p><strong><em>* Limitations of using free testosterone by equilibrium dialysis and calculated free testosterone concentrations in practice are the <u>lack of assay standardization, an accuracy-based quality control program, and a harmonized reference range</u>. Until these <u>limitations are addressed</u>, free testosterone by equilibrium dialysis and calculated free testosterone should use <u>reference ranges established by individual laboratories or their specific assay method</u></em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 279569, member: 13851"] Even then we need to wait on harmonized FT reference ranges based on a standardized FT assay (ED-LC/MS/MS). Similar to what was done for harmonized TT. [B][I]*Assays that are [U]standardized are designed to provide accurate results, traceable to “true” value-assigned certified reference materials and gold-standard reference methods[/U].[/I][/B] The CDC has been working hard on this and it is not too far off now! Soon enough we will have a CDC Hormone Standardization Program (CDC HoSt) Certified Free Testosterone Procedure and a harmonized reference range for free testosterone! [URL unfurl="true"]https://www.excelmale.com/threads/cdc%E2%80%99s-clinical-standardization-programs-cdc-csp-ensuring-the-accuracy-and-reliability-of-chronic-disease-biomarker-tests.30192/[/URL] [ATTACH type="full" alt="1713723546039.png"]43656[/ATTACH] Something to keep in mind when it comes to using/relying upon the calculated FT methods! [B][I]*Currently, the CDC is developing a [U]harmonized method for free T based on calculated free T using REVISED FORMULAE.[/U] This may bring the measurement of free T to a [U]referable standard[/U] in clinical laboratories and [U]common reference intervals[/U] that all clinicians can use[/I][/B] [URL unfurl="true"]https://www.excelmale.com/threads/how-to-co-relate-ria-and-equilibrium-dialysis-reports.30209/#post-278995[/URL] Take home points: [I][B]*Assays that are [U]standardized are designed to provide accurate results, traceable to “true” value-assigned certified reference materials and gold-standard reference methods[/U]. [U]Results obtained using standardized methods can be compared across assays, institutions, populations, and past and future test results, thereby improving diagnosis, treatment, and outcomes of patients[/U][/B][/I] [B][I]* Limitations of using free testosterone by equilibrium dialysis and calculated free testosterone concentrations in practice are the [U]lack of assay standardization, an accuracy-based quality control program, and a harmonized reference range[/U]. Until these [U]limitations are addressed[/U], free testosterone by equilibrium dialysis and calculated free testosterone should use [U]reference ranges established by individual laboratories or their specific assay method[/U][/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
AGE SPECIFIC CALCULATED FREE TESTOSTERONE RANGES IN ADULT MEN
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