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General Health & Fitness
Nutrition and Supplements
you need to avoid seed oils (PUFA's)
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<blockquote data-quote="Cataceous" data-source="post: 279360" data-attributes="member: 38109"><p>Theoretical risks versus favorable observational studies. The jury is still out. Credit to Wiki for the references:</p><p></p><p style="margin-left: 20px"><em>In prospective cohort studies, higher LA intake, assessed by dietary surveys or biomarkers, was associated with a modestly lower risk of mortality from all causes, CVD, and cancer. These data support the potential long-term benefits of PUFA intake in lowering the risk of CVD and premature death.</em></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326588/[/URL]</p><p></p><p style="margin-left: 20px"><em>Overall, data from clinical studies and meta-analyses suggest an association between high dietary intakes or tissue levels of n-6 PUFA, and specifically LA, and the improvement of cardiovascular risk (mainly of the plasma lipid profile), as well as long-term glycaemic control and insulin resistance. ... <strong>High quality clinical trials are needed to assess both the actual amplitude and the underlying mechanisms of the health effects related to dietary intake of this essential fatty acid.</strong></em></p><p>...</p><p style="margin-left: 20px"><em>In particular, for years emphasis has been placed on the potential pro-inflammatory properties of some n-6 PUFA metabolites (e.g. some of the eicosanoids deriving from AA) [8] and on the competition between LA and ALA as substrates for the same metabolic pathway, possibly leading to reduced levels of the ALA derived n-3 long chain PUFA (LC-PUFA) in organs and tissues [9].</em></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Yet, epidemiological studies indicate that an adequate intake of LA is associated with lower levels of plasma low-density lipoprotein cholesterol (LDL-C) [10], and <strong>dietary intervention studies have shown that replacing 5% of the dietary energy derived from SFA with n-6 PUFA reduces LDL-C by up to 10%, consequently resulting in a significant reduction of CVD risk</strong> [11,12]. Furthermore, a diet enriched in n-6 PUFA reduced liver fat and resulted in a modestly improved metabolic status, with no signs of inflammation, compared with a diet enriched in SFA, in subjects with abdominal obesity [13]. Moreover, it has been observed that circulating concentrations of LA are inversely associated with incident type 2 diabetes in prospective cohort studies [14].</em></p><p>[URL unfurl="true"]https://www.sciencedirect.com/science/article/abs/pii/S0021915019315758[/URL]</p><p></p><p style="margin-left: 20px"><em><strong>We found that a high intake of dietary LA and elevated concentrations of LA in the body were both significantly associated with a lower risk of T2DM</strong>. These findings support dietary recommendations to consume dietary LA.</em></p><p>[URL unfurl="true"]https://diabetesjournals.org/care/article/44/9/2173/138865/Dietary-Intake-of-Linoleic-Acid-Its-Concentrations[/URL]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 279360, member: 38109"] Theoretical risks versus favorable observational studies. The jury is still out. Credit to Wiki for the references: [INDENT][I]In prospective cohort studies, higher LA intake, assessed by dietary surveys or biomarkers, was associated with a modestly lower risk of mortality from all causes, CVD, and cancer. These data support the potential long-term benefits of PUFA intake in lowering the risk of CVD and premature death.[/I][/INDENT] [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326588/[/URL] [INDENT][I]Overall, data from clinical studies and meta-analyses suggest an association between high dietary intakes or tissue levels of n-6 PUFA, and specifically LA, and the improvement of cardiovascular risk (mainly of the plasma lipid profile), as well as long-term glycaemic control and insulin resistance. ... [B]High quality clinical trials are needed to assess both the actual amplitude and the underlying mechanisms of the health effects related to dietary intake of this essential fatty acid.[/B][/I][/INDENT] ... [INDENT][I]In particular, for years emphasis has been placed on the potential pro-inflammatory properties of some n-6 PUFA metabolites (e.g. some of the eicosanoids deriving from AA) [8] and on the competition between LA and ALA as substrates for the same metabolic pathway, possibly leading to reduced levels of the ALA derived n-3 long chain PUFA (LC-PUFA) in organs and tissues [9].[/I][/INDENT] [INDENT][I][/I][/INDENT] [INDENT][I]Yet, epidemiological studies indicate that an adequate intake of LA is associated with lower levels of plasma low-density lipoprotein cholesterol (LDL-C) [10], and [B]dietary intervention studies have shown that replacing 5% of the dietary energy derived from SFA with n-6 PUFA reduces LDL-C by up to 10%, consequently resulting in a significant reduction of CVD risk[/B] [11,12]. Furthermore, a diet enriched in n-6 PUFA reduced liver fat and resulted in a modestly improved metabolic status, with no signs of inflammation, compared with a diet enriched in SFA, in subjects with abdominal obesity [13]. Moreover, it has been observed that circulating concentrations of LA are inversely associated with incident type 2 diabetes in prospective cohort studies [14].[/I][/INDENT] [URL unfurl="true"]https://www.sciencedirect.com/science/article/abs/pii/S0021915019315758[/URL] [INDENT][I][B]We found that a high intake of dietary LA and elevated concentrations of LA in the body were both significantly associated with a lower risk of T2DM[/B]. These findings support dietary recommendations to consume dietary LA.[/I][/INDENT] [URL unfurl="true"]https://diabetesjournals.org/care/article/44/9/2173/138865/Dietary-Intake-of-Linoleic-Acid-Its-Concentrations[/URL] [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
you need to avoid seed oils (PUFA's)
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