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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?
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<blockquote data-quote="madman" data-source="post: 203877" data-attributes="member: 13851"><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/effect-of-trt-vs-hcg-fsh-on-upstream-hormone-pathways.21696/[/URL]</p><p></p><p></p><p><strong>Treatment protocols</strong></p><p></p><p>Subcutaneous hCG and rFSH injections were administered to CHH males for 2-4 years, according to a protocol as described previously 10, until testicular maturation was accomplished. <strong><em>Specifically, in <u>pre-pubertal patients, a starting dose of 500 IU hCG was injected subcutaneously twice weekly</u>. <u>Incremental increases every 3-6 months to a maximum of 2-3 x 1500 IU hCG s.c./week were administered, if necessary, to achieve serum T levels in the mid-normal adult range</u></em></strong><em><strong> (T>3.5 ng/ml, [12 nmol/l]) by one year after the start of hCG. <u>In post-pubertal men who had previously received exogenous T, a starting </u></strong></em><strong><em><u>dose of 2 x 1000-1500 IU hCG s.c./week was applied, aiming at adult serum T levels by 3 months. After 3(-6) months of hCG treatment, rFSH was added at a standard dose of 3x 150 IE s.c./week</u>. This combined replacement was continued until gonadal maturation was achieved, as indicated by plateauing sperm concentrations in semen and achievement of maximal testicular volumes.</em></strong> Thereafter, males were switched to exogenous T substitution, either by application of T gel or by i.m. injections of T enanthate or T undecanoate. Doses were adjusted after 3 months of treatment, to achieve serum T levels in the mid-normal adult range.</p><p></p><p></p><p></p><p></p><p><strong>Figure 4</strong></p><p><em>-Serum steroid hormone concentrations of CHH males from alternative/backdoor pathways of androgen biosynthesis</em></p><p><em></em></p><p><em>-Serum androstenediol concentrations, representing the alternative pathway of testosterone formation, in CHH males on hCG/rFSH and T replacement, compared to those of healthy controls.</em></p><p><em></em></p><p><em>-Serum androstanediol concentrations, representing the backdoor pathway of DHT formation in CHH males, on gonadotropin and T replacement, and in healthy controls.</em></p><p><em></em></p><p><em>-Serum 11K T and 11 K DHT concentrations, representing the 11-oxygenated C19 androgen pathway in CHH males, on gonadotropin and T replacement, and in healthy controls.</em></p><p></p><p>[ATTACH=full]15291[/ATTACH]</p><p>[ATTACH=full]15292[/ATTACH]</p><p>[ATTACH=full]15293[/ATTACH]</p><p>[ATTACH=full]15294[/ATTACH]</p><p></p><p></p><p></p><p></p><p></p><p><strong>Figure 3</strong></p><p><em>-Serum steroid hormone concentrations from Δ5 and Δ4 pathways of CHH males (including testosterone metabolites) analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), once, while patients were undergoing hCG/rFSH treatment and again, while they were on T replacement, compared to those of healthy matched controls.</em></p><p></p><p>[ATTACH=full]15295[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 203877, member: 13851"] [URL unfurl="true"]https://www.excelmale.com/forum/threads/effect-of-trt-vs-hcg-fsh-on-upstream-hormone-pathways.21696/[/URL] [B]Treatment protocols[/B] Subcutaneous hCG and rFSH injections were administered to CHH males for 2-4 years, according to a protocol as described previously 10, until testicular maturation was accomplished. [B][I]Specifically, in [U]pre-pubertal patients, a starting dose of 500 IU hCG was injected subcutaneously twice weekly[/U]. [U]Incremental increases every 3-6 months to a maximum of 2-3 x 1500 IU hCG s.c./week were administered, if necessary, to achieve serum T levels in the mid-normal adult range[/U][/I][/B][I][B] (T>3.5 ng/ml, [12 nmol/l]) by one year after the start of hCG. [U]In post-pubertal men who had previously received exogenous T, a starting [/U][/B][/I][B][I][U]dose of 2 x 1000-1500 IU hCG s.c./week was applied, aiming at adult serum T levels by 3 months. After 3(-6) months of hCG treatment, rFSH was added at a standard dose of 3x 150 IE s.c./week[/U]. This combined replacement was continued until gonadal maturation was achieved, as indicated by plateauing sperm concentrations in semen and achievement of maximal testicular volumes.[/I][/B] Thereafter, males were switched to exogenous T substitution, either by application of T gel or by i.m. injections of T enanthate or T undecanoate. Doses were adjusted after 3 months of treatment, to achieve serum T levels in the mid-normal adult range. [B]Figure 4[/B] [I]-Serum steroid hormone concentrations of CHH males from alternative/backdoor pathways of androgen biosynthesis -Serum androstenediol concentrations, representing the alternative pathway of testosterone formation, in CHH males on hCG/rFSH and T replacement, compared to those of healthy controls. -Serum androstanediol concentrations, representing the backdoor pathway of DHT formation in CHH males, on gonadotropin and T replacement, and in healthy controls. -Serum 11K T and 11 K DHT concentrations, representing the 11-oxygenated C19 androgen pathway in CHH males, on gonadotropin and T replacement, and in healthy controls.[/I] [ATTACH type="full" alt="Screenshot (5759).png"]15291[/ATTACH] [ATTACH type="full" alt="Screenshot (5760).png"]15292[/ATTACH] [ATTACH type="full" alt="Screenshot (5761).png"]15293[/ATTACH] [ATTACH type="full" alt="Screenshot (5762).png"]15294[/ATTACH] [B]Figure 3[/B] [I]-Serum steroid hormone concentrations from Δ5 and Δ4 pathways of CHH males (including testosterone metabolites) analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), once, while patients were undergoing hCG/rFSH treatment and again, while they were on T replacement, compared to those of healthy matched controls.[/I] [ATTACH type="full" alt="Screenshot (5763).png"]15295[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?
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