ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Tri-Mix
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 17155" data-attributes="member: 3"><p><em><strong>TriMix: Papaverine,Phentolamine, Alprostadil</strong></em></p><p><em><strong></strong></em></p><p>TriMix is a compounded medication the combine’s papaverine, phentolamine and alprostadil in one vial to achieve maximum efficacy, lower incidence of pain,and lower cost per dose. Studies have been done that have shown the efficacy of all three agents combined into one formulation. Combination therapy was first introduced in 1991 by Bennett and his colleagues who demonstrated a success rate of TriMix of 92% in 116 patients. TriMix is often reserved for patients who fail alprostadil (PGE-1), fail Bi-Mix or for patients with severe penile pain from prostaglandin E1. Since TriMix uses lower doses of alprostadil,penile pain often subsides.</p><p></p><p>- Usual prescribed strength: Papaverine 18-25mg + Phentolamine 1.0-2.0mg +Prostaglandin E1 10-25mcg/ml</p><p><em><em></em></em></p><p><em><em></em></em></p><p><em><em></em></em></p><p><em><em>Alprostodil </em></em></p><p><em><em></em></em></p><p><em><em>- Commercially available for monotherapy as Caverject® and Edex®</em></em></p><p><em><em>- Mechanism: a prostaglandin E1 that stimulates the relaxation of the smooth muscle and dilates arteries in the penis increasing blood flow</em></em></p><p><em><em>- Studies have shown efficacy in 75% of men when injected into the penis</em></em></p><p><em><em>- Usual dose: start at 10-15 mcg inpatients who have failed oral therapy or 2.5-5 mcg in patients who have neurogenic or psychogenic ED and have failed or declined oral therapy</em></em></p><p><em><em>- Median dose is 12-15 mcg. Benefit is not seen at doses greater than 40 mcg. It is recommended to try a drug combination that includes papaverine, phentolamine or both. </em></em></p><p><em><em></em></em></p><p><em><em>- Side Effects</em></em></p><p><em><em></em></em></p><p><em><em>o Priapism: prolonged erection lasting more than 4 hours- must seek medical attention</em></em></p><p><em><em>o Penile pain- during or immediately after injection, occurs in upto 31%, may be reduced if mixed with other agents</em></em></p><p><em><em>o Bruising at injection site- can be minimized with a 30G needle,should be minimal with proper injection technique </em></em></p><p><em><em>o Hypotension- occurs when drug leaks out of injected area intogeneral circulation. Rare with alprostadil.</em></em></p><p><em><em>o Fibrosis- scaring of penile tissue is lower with alprostadil, mayresult after long term use of injection therapy </em></em></p><p><em><em>o Occasional increase in liver function tests</em></em></p><p><em><em></em></em></p><p><em><em><em>Phentolamine</em></em></em></p><p><em><em><em></em></em></em></p><p><em><em><em>- Commercially available as Regitine®</em></em></em></p><p><em><em><em>- Mechanism: alpha-adrenergic antagonist that produces a direct vasodilation in the arteries increasing blood flow to thepenis. </em></em></em></p><p><em><em><em>- Usual Dose: 1 to 2 mg </em></em></em></p><p><em><em><em></em></em></em></p><p><em><em><em>- Side Effects </em></em></em></p><p><em><em><em></em></em></em></p><p><em><em><em>o Painful prolonged erection lasting more than 4 hours</em></em></em></p><p><em><em><em>o Fibrosis- penile scaring </em></em></em></p><p><em><em><em>o Systemic hypotension (low blood pressure)</em></em></em></p><p><em><em><em>o Reflex tachycardia (increase in heart rate)</em></em></em></p><p><em><em><em>o Nasal congestion</em></em></em></p><p><em><em><em>o Gastrointestinal upset</em></em></em></p><p><em><em><em></em></em></em></p><p><em><em><em><em>Papaverine</em></em></em></em></p><p><em><em><em><em></em></em></em></em></p><p><em><em><em><em>- Not commercially available and must be used with phentolamine to produce hard erections. </em></em></em></em></p><p><em><em><em><em>- Mechanism: Phosphodiesterase inhibitor that results in smooth muscle relaxation allowing for an increase in blood flow to the penis. It’s used mainly in combination with alprostadil and/or phentolamine. Although it has been used since the early 1980’s, it is not approved for ED. </em></em></em></em></p><p><em><em><em><em>- Usual dose ranges from 5 to 30 mg</em></em></em></em></p><p><em><em><em><em></em></em></em></em></p><p><em><em><em><em>- Side effects </em></em></em></em></p><p><em><em><em><em></em></em></em></em></p><p><em><em><em><em>o Priapism- high rate of 1-6%</em></em></em></em></p><p><em><em><em><em>o Fibrosis- highest rate and can present as a lump within the penis</em></em></em></em></p><p><em><em><em><em>o Hypotension</em></em></em></em></p><p><em><em><em><em></em></em></em></em></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 17155, member: 3"] [I][/I][I][B]TriMix: Papaverine,Phentolamine, Alprostadil [/B][/I] TriMix is a compounded medication the combine’s papaverine, phentolamine and alprostadil in one vial to achieve maximum efficacy, lower incidence of pain,and lower cost per dose. Studies have been done that have shown the efficacy of all three agents combined into one formulation. Combination therapy was first introduced in 1991 by Bennett and his colleagues who demonstrated a success rate of TriMix of 92% in 116 patients. TriMix is often reserved for patients who fail alprostadil (PGE-1), fail Bi-Mix or for patients with severe penile pain from prostaglandin E1. Since TriMix uses lower doses of alprostadil,penile pain often subsides. - Usual prescribed strength: Papaverine 18-25mg + Phentolamine 1.0-2.0mg +Prostaglandin E1 10-25mcg/ml [I][I] Alprostodil - Commercially available for monotherapy as Caverject® and Edex® - Mechanism: a prostaglandin E1 that stimulates the relaxation of the smooth muscle and dilates arteries in the penis increasing blood flow - Studies have shown efficacy in 75% of men when injected into the penis - Usual dose: start at 10-15 mcg inpatients who have failed oral therapy or 2.5-5 mcg in patients who have neurogenic or psychogenic ED and have failed or declined oral therapy - Median dose is 12-15 mcg. Benefit is not seen at doses greater than 40 mcg. It is recommended to try a drug combination that includes papaverine, phentolamine or both. - Side Effects o Priapism: prolonged erection lasting more than 4 hours- must seek medical attention o Penile pain- during or immediately after injection, occurs in upto 31%, may be reduced if mixed with other agents o Bruising at injection site- can be minimized with a 30G needle,should be minimal with proper injection technique o Hypotension- occurs when drug leaks out of injected area intogeneral circulation. Rare with alprostadil. o Fibrosis- scaring of penile tissue is lower with alprostadil, mayresult after long term use of injection therapy o Occasional increase in liver function tests [I]Phentolamine - Commercially available as Regitine® - Mechanism: alpha-adrenergic antagonist that produces a direct vasodilation in the arteries increasing blood flow to thepenis. - Usual Dose: 1 to 2 mg - Side Effects o Painful prolonged erection lasting more than 4 hours o Fibrosis- penile scaring o Systemic hypotension (low blood pressure) o Reflex tachycardia (increase in heart rate) o Nasal congestion o Gastrointestinal upset [I]Papaverine - Not commercially available and must be used with phentolamine to produce hard erections. - Mechanism: Phosphodiesterase inhibitor that results in smooth muscle relaxation allowing for an increase in blood flow to the penis. It’s used mainly in combination with alprostadil and/or phentolamine. Although it has been used since the early 1980’s, it is not approved for ED. - Usual dose ranges from 5 to 30 mg - Side effects o Priapism- high rate of 1-6% o Fibrosis- highest rate and can present as a lump within the penis o Hypotension [/I][/I][/I][/I] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Tri-Mix
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top