ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Tadalafil (Cialis) Decreases Estradiol.
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 20494" data-attributes="member: 3"><p><strong>ABSTRACT</strong></p><p></p><p>Introduction. It has been reported that lack of sexual activity due to erectile dysfunction (ED) may be associated with testosterone (T) decline.</p><p></p><p>Aim. To investigate whether the known changes in sex hormones associated with resumption of sexual activity are sustained in the long term.</p><p></p><p>Main Outcome Measures. Primary endpoints were variations from baseline of steroid hormones: total T, free T (f T), and estradiol (E). Secondary endpoints were variations of erectile function domain scores at International Index of Erectile Function-5 (IIEF-5).</p><p></p><p>Methods. In an open-label fashion, 20 patients (mean age 54.8 ± 8.4 years) received tadalafil 10–20 mg on demand for 12 months. Exclusion criteria were those reported for phosphodiesterase inhibitors, including hypogonadism and hyperprolactinemia.</p><p></p><p>Results. Tadalafil assumption was safe and well tolerated (overall adverse effects in 15% of patients) and none discontinued medication. A significant decrease in E levels occurred at the end of the study (from 19.9 ± 9.6 to 16.6 ± 8.1 ng/dL, <em>P</em> = 0.042 vs. baseline), with parallel increase in the T:E ratio (26.3 ± 15.3 to 32.6 ± 17.7, <em>P</em> = 0.05), whereas no changes in T and f T serum levels were observed, respectively (411.4 ± 131.4 to 434.2 ± 177.1 ng/dL and 47.7 ± 15.3 to 49.9 ± 19.1 pmol/L, not significant). Interestingly, nonparametric subgroup analysis for related samples revealed that E decrease was detectable only in lean (N = 14) but not in obese (N = 6, body mass index > 27.5 kg/m[SUP]2[/SUP]) subjects (17.8 ± 10.1 vs. 13.5 ± 6.8, <em>P</em> < 0.05). A net increase in IIEF-5 scores was observed at the endpoint (13.7 ± 5.9 vs. 25.7 ± 2.9, <em>P</em> < 0.0001).</p><p></p><p>Conclusions. Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen–estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil might have a role in the regulation of erectile function. </p><p></p><p></p><p>Greco EA, Pili M, Bruzziches R, Corona G, Spera G, and Aversa A. Testosterone:estradiol ratio changes associated with long-term tadalafil administration: A pilot study. J Sex Med 2006;3:716–722.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 20494, member: 3"] [B]ABSTRACT[/B] Introduction. It has been reported that lack of sexual activity due to erectile dysfunction (ED) may be associated with testosterone (T) decline. Aim. To investigate whether the known changes in sex hormones associated with resumption of sexual activity are sustained in the long term. Main Outcome Measures. Primary endpoints were variations from baseline of steroid hormones: total T, free T (f T), and estradiol (E). Secondary endpoints were variations of erectile function domain scores at International Index of Erectile Function-5 (IIEF-5). Methods. In an open-label fashion, 20 patients (mean age 54.8 ± 8.4 years) received tadalafil 10–20 mg on demand for 12 months. Exclusion criteria were those reported for phosphodiesterase inhibitors, including hypogonadism and hyperprolactinemia. Results. Tadalafil assumption was safe and well tolerated (overall adverse effects in 15% of patients) and none discontinued medication. A significant decrease in E levels occurred at the end of the study (from 19.9 ± 9.6 to 16.6 ± 8.1 ng/dL, [I]P[/I] = 0.042 vs. baseline), with parallel increase in the T:E ratio (26.3 ± 15.3 to 32.6 ± 17.7, [I]P[/I] = 0.05), whereas no changes in T and f T serum levels were observed, respectively (411.4 ± 131.4 to 434.2 ± 177.1 ng/dL and 47.7 ± 15.3 to 49.9 ± 19.1 pmol/L, not significant). Interestingly, nonparametric subgroup analysis for related samples revealed that E decrease was detectable only in lean (N = 14) but not in obese (N = 6, body mass index > 27.5 kg/m[SUP]2[/SUP]) subjects (17.8 ± 10.1 vs. 13.5 ± 6.8, [I]P[/I] < 0.05). A net increase in IIEF-5 scores was observed at the endpoint (13.7 ± 5.9 vs. 25.7 ± 2.9, [I]P[/I] < 0.0001). Conclusions. Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen–estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil might have a role in the regulation of erectile function. Greco EA, Pili M, Bruzziches R, Corona G, Spera G, and Aversa A. Testosterone:estradiol ratio changes associated with long-term tadalafil administration: A pilot study. J Sex Med 2006;3:716–722. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Tadalafil (Cialis) Decreases Estradiol.
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top