ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Recent blood tests don't match up
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Nelson Vergel" data-source="post: 17591" data-attributes="member: 3"><p>Letrozole, like any other aromatase inhibitor, increases testosterone. The increase is usually not "felt" by the men who use it as monotherapy.</p><p></p><p></p><p>You were taking a high dose, by the way!</p><p></p><p></p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/18426834#" target="_blank">Eur J Endocrinol.</a> 2008 May;158(5):741-7. doi: 10.1530/EJE-07-0663.</p><p><strong>Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism.</strong><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Loves%20S%5BAuthor%5D&cauthor=true&cauthor_uid=18426834" target="_blank">Loves S</a>1, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Ruinemans-Koerts%20J%5BAuthor%5D&cauthor=true&cauthor_uid=18426834" target="_blank">Ruinemans-Koerts J</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=de%20Boer%20H%5BAuthor%5D&cauthor=true&cauthor_uid=18426834" target="_blank">de Boer H</a>.</p><p>[h=3]<a href="http://www.ncbi.nlm.nih.gov/pubmed/18426834#" target="_blank">Author information</a>[/b]</p><p></p><p>[h=3]Abstract[/b][h=4]OBJECTIVE:[/b]Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E(2)) production and E(2)-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can reverse this process. This study evaluates whether letrozole once a week can normalize serum testosterone in severely obese men and maintain its long term effect.</p><p>[h=4]DESIGN:[/b]Open, uncontrolled 6-month pilot study in 12 severely obese men (body mass index>35.0 kg/m(2)) with obesity-related IHH and free testosterone levels <225 pmol/l, treated with 2.5 mg letrozole once a week for 6 months.</p><p>[h=4]RESULTS:[/b]Six weeks of treatment reduced total E(2) from 123+/-11 to 58+/-7 pmol/l (P<0.001, mean+/-s.e.m.), and increased serum LH from 4.4+/-0.6 to 11.1+/-1.5 U/l (P<0.001). Total testosterone rose from 5.9+/-0.5 to 19.6+/-1.4 nmol/l (P<0.001), and free testosterone from 163+/-13 to 604+/-50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men. The testosterone and E(2) levels were stable throughout the week and during the 6-month treatment period.</p><p>[h=4]CONCLUSION:[/b]Letrozole 2.5 mg once a week produced a sustained normalization of serum total testosterone in obese men with IHH. However, free testosterone frequently rose to supraphysiological levels. Therefore, a starting dose <2.5 mg once a week is recommended.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 17591, member: 3"] Letrozole, like any other aromatase inhibitor, increases testosterone. The increase is usually not "felt" by the men who use it as monotherapy. You were taking a high dose, by the way! [URL="http://www.ncbi.nlm.nih.gov/pubmed/18426834#"]Eur J Endocrinol.[/URL] 2008 May;158(5):741-7. doi: 10.1530/EJE-07-0663. [b]Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism.[/b][URL="http://www.ncbi.nlm.nih.gov/pubmed/?term=Loves%20S%5BAuthor%5D&cauthor=true&cauthor_uid=18426834"]Loves S[/URL]1, [URL="http://www.ncbi.nlm.nih.gov/pubmed/?term=Ruinemans-Koerts%20J%5BAuthor%5D&cauthor=true&cauthor_uid=18426834"]Ruinemans-Koerts J[/URL], [URL="http://www.ncbi.nlm.nih.gov/pubmed/?term=de%20Boer%20H%5BAuthor%5D&cauthor=true&cauthor_uid=18426834"]de Boer H[/URL]. [h=3][URL="http://www.ncbi.nlm.nih.gov/pubmed/18426834#"]Author information[/URL][/b] [h=3]Abstract[/b][h=4]OBJECTIVE:[/b]Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E(2)) production and E(2)-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can reverse this process. This study evaluates whether letrozole once a week can normalize serum testosterone in severely obese men and maintain its long term effect. [h=4]DESIGN:[/b]Open, uncontrolled 6-month pilot study in 12 severely obese men (body mass index>35.0 kg/m(2)) with obesity-related IHH and free testosterone levels <225 pmol/l, treated with 2.5 mg letrozole once a week for 6 months. [h=4]RESULTS:[/b]Six weeks of treatment reduced total E(2) from 123+/-11 to 58+/-7 pmol/l (P<0.001, mean+/-s.e.m.), and increased serum LH from 4.4+/-0.6 to 11.1+/-1.5 U/l (P<0.001). Total testosterone rose from 5.9+/-0.5 to 19.6+/-1.4 nmol/l (P<0.001), and free testosterone from 163+/-13 to 604+/-50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men. The testosterone and E(2) levels were stable throughout the week and during the 6-month treatment period. [h=4]CONCLUSION:[/b]Letrozole 2.5 mg once a week produced a sustained normalization of serum total testosterone in obese men with IHH. However, free testosterone frequently rose to supraphysiological levels. Therefore, a starting dose <2.5 mg once a week is recommended. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Recent blood tests don't match up
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top