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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Raising ferritin FAST (a how-to, not a question)
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<blockquote data-quote="FDV70" data-source="post: 209621" data-attributes="member: 43104"><p>That was my heme's conception of what would happen. He knows TRT and his practice deals with a few guys like us. I said 30 is too much doc, it makes me nervous and years of donating I don't want to make myself worse. So he said allright take 25 or 20. His idea is that it should keep hepcidin up, allowing ferritin to rise over time. But my concern is the downward pressure of TRT keeping hepcidin low and my HGB going up.</p><p></p><p>I have a group of guys doing this and one reported that although his ferritin did fully restore, he did daily iron of IIRC 28mg and he had to donate a month earlier. So that scared me and I stopped my daily. (Me: TRT 20 years, donating around 18, scar tissue in my veins, so I am way more of a chickensh-t on this than most really.) I was just happy to get my ferritin to pre-donation levels.</p><p></p><p>From my research, it's the initial loading dose of 60+ that elevates hepcidin enough to pull this off reliably. The lower daily dosing I just don't know, because it's once daily not 3x. Unknown territory now, and I depend on guys testing on themselves to get a sense.</p><p></p><p>"Also makes me wonder if frequent donators like myself who have crashed ferritin had lower levels to start with in comparison to trt guys that never need to donate."</p><p></p><p>I suspect that's exactly right. I have a suspicion that a biological cutoff for ferritin exists for _anyone_ on TRT, even if they don't need to donate, and ferritin won't stay up (unless they have some disease or something). I would love to see data showing donor and "never had to donate" guys on TRT over a year and their mean, median, and mode ferritin levels.</p><p></p><p>Over time, the idea that HCT would be lower from daily dosing makes me suspicious. I will say this. Before I decided on the 3x per day, I was doing 2x per day. On June 8th:</p><p>RBC-6.34</p><p>HGB-16.9</p><p>HCT-52.5</p><p>I did 60mg iron@9am, and 3pm for a few days, then stopped. Went to get a blood test and came up with:</p><p>RBC-6.05</p><p>HGB-16</p><p>HCT-49</p><p>My heme asked me ALL the questions. Could it have been dehydration? I was well hydrated both times (and a drop in RBCs like that would be really dramatic for hydration issues. Could be.) Could be lab error. In any case I got a month reprieve from donating. But this got him all excited and had him encouraging me to go up to 3x per day.</p><p>Sadly, I was unable to replicate this, although a drop did make sense, in my case this is all just too imprecise. So that's why I mainly just rely on this for ferritin restoration.</p><p></p><p>When you read, you saw the information about Rusfertide. Rusfertide (which is a knock-off of human hepcidin) does this exact thing, lowers the RBC's and HGB etc. So when my process seemed to work my heme was sold. It is my hope that some other peptide company will create their own and offer it. If you compare Rusfertide and human hepcidin on pubchem, they are clearly in the same neighborhood, and my point here is that if they tweak it, they could come up with something new that would likely work and could try again. But this is a really long winded way for me to say that I don't think daily iron can really keep H&H down -- I think we're going to have to use actual hepcidin itself, sub-q.</p><p></p><p>"HCT increases regardless of dose."</p><p></p><p>Me too. My heme tested my EPO level and it was 20 or 21 I forget. After two decades. Clearly the "new set point" isn't doing me any good.</p><p></p><p>"Thanks for the write up!"</p><p></p><p>My pleasure! I hope it catches on as a post donation recovery method. No question it works, now we just have to optimize it. I am going to be ordering bulk Adenine (hepcidin agonist) next time. Maybe that will amplify the effect. If/when you try, report in so I can get a sense of different success rates.</p></blockquote><p></p>
[QUOTE="FDV70, post: 209621, member: 43104"] That was my heme's conception of what would happen. He knows TRT and his practice deals with a few guys like us. I said 30 is too much doc, it makes me nervous and years of donating I don't want to make myself worse. So he said allright take 25 or 20. His idea is that it should keep hepcidin up, allowing ferritin to rise over time. But my concern is the downward pressure of TRT keeping hepcidin low and my HGB going up. I have a group of guys doing this and one reported that although his ferritin did fully restore, he did daily iron of IIRC 28mg and he had to donate a month earlier. So that scared me and I stopped my daily. (Me: TRT 20 years, donating around 18, scar tissue in my veins, so I am way more of a chickensh-t on this than most really.) I was just happy to get my ferritin to pre-donation levels. From my research, it's the initial loading dose of 60+ that elevates hepcidin enough to pull this off reliably. The lower daily dosing I just don't know, because it's once daily not 3x. Unknown territory now, and I depend on guys testing on themselves to get a sense. "Also makes me wonder if frequent donators like myself who have crashed ferritin had lower levels to start with in comparison to trt guys that never need to donate." I suspect that's exactly right. I have a suspicion that a biological cutoff for ferritin exists for _anyone_ on TRT, even if they don't need to donate, and ferritin won't stay up (unless they have some disease or something). I would love to see data showing donor and "never had to donate" guys on TRT over a year and their mean, median, and mode ferritin levels. Over time, the idea that HCT would be lower from daily dosing makes me suspicious. I will say this. Before I decided on the 3x per day, I was doing 2x per day. On June 8th: RBC-6.34 HGB-16.9 HCT-52.5 I did 60mg iron@9am, and 3pm for a few days, then stopped. Went to get a blood test and came up with: RBC-6.05 HGB-16 HCT-49 My heme asked me ALL the questions. Could it have been dehydration? I was well hydrated both times (and a drop in RBCs like that would be really dramatic for hydration issues. Could be.) Could be lab error. In any case I got a month reprieve from donating. But this got him all excited and had him encouraging me to go up to 3x per day. Sadly, I was unable to replicate this, although a drop did make sense, in my case this is all just too imprecise. So that's why I mainly just rely on this for ferritin restoration. When you read, you saw the information about Rusfertide. Rusfertide (which is a knock-off of human hepcidin) does this exact thing, lowers the RBC's and HGB etc. So when my process seemed to work my heme was sold. It is my hope that some other peptide company will create their own and offer it. If you compare Rusfertide and human hepcidin on pubchem, they are clearly in the same neighborhood, and my point here is that if they tweak it, they could come up with something new that would likely work and could try again. But this is a really long winded way for me to say that I don't think daily iron can really keep H&H down -- I think we're going to have to use actual hepcidin itself, sub-q. "HCT increases regardless of dose." Me too. My heme tested my EPO level and it was 20 or 21 I forget. After two decades. Clearly the "new set point" isn't doing me any good. "Thanks for the write up!" My pleasure! I hope it catches on as a post donation recovery method. No question it works, now we just have to optimize it. I am going to be ordering bulk Adenine (hepcidin agonist) next time. Maybe that will amplify the effect. If/when you try, report in so I can get a sense of different success rates. [/QUOTE]
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Raising ferritin FAST (a how-to, not a question)
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