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<blockquote data-quote="The Dude" data-source="post: 13314" data-attributes="member: 2592">So we know that cGMP allows an erection to occur, and PDE5 is responsible for turning it off.The fact that PDE5 inhibitors (Cialis,Viagra,Levitra) are a spectacular financial success has two big implications:1 - everyone who finds that PDE5 inhibitors work - which is roughly two-thirds of those who try them - must have no problem producing nitric oxide and cGMP, otherwise it would not work.2 - The fact that PDE5 inhibitors solve the problem for most older guys, indicates that PDE5 production increases as we age.I've done a lot of web searching and amazingly, cannot find any discussion on the latter point, which seems to me a very big issue.This is likely due to:A - The current difficulty of searching for anything having to do with the issue.&nbsp; There seem to be thousands, maybe millions of bot-generated web pages that have a sentence or two of medical research on PDE5, followed by &quot; Buy at best price at Joe's Safe Online Pharmacy dot com !! &quot;.B - The vast billions of dollars at stake seems to have the medical researchers tight lipped on anything having to do with PDE5, beyond the Wikipedia description.So, I was curious if anyone on this board has read any discussions about why and how the PDE5 production increases as we age ? Thanks !</blockquote>

[QUOTE="The Dude, post: 13314, member: 2592"] So we know that cGMP allows an erection to occur, and PDE5 is responsible for turning it off. The fact that PDE5 inhibitors (Cialis,Viagra,Levitra) are a spectacular financial success has two big implications: 1 - everyone who finds that PDE5 inhibitors work - which is roughly two-thirds of those who try them - must have no problem producing nitric oxide and cGMP, otherwise it would not work. 2 - The fact that PDE5 inhibitors solve the problem for most older guys, indicates [B]that PDE5 production increases as we age.[/B] I've done a lot of web searching and amazingly, cannot find any discussion on the latter point, which seems to me a very big issue. This is likely due to: A - The current difficulty of searching for anything having to do with the issue. There seem to be thousands, maybe millions of bot-generated web pages that have a sentence or two of medical research on PDE5, followed by " Buy at best price at Joe's Safe Online Pharmacy dot com !! ". B - The vast billions of dollars at stake seems to have the medical researchers tight lipped on anything having to do with PDE5, beyond the Wikipedia description. So, I was curious if anyone on this board has read any discussions about why and how the PDE5 production increases as we age ? Thanks ! [/QUOTE]

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